Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.117722 | 1 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.117722 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0419704 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0757515 | 0.445946 | 0.445946 |
Schistosoma mansoni | AMP deaminase | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.117722 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.117722 | 1 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Toxoplasma gondii | AMP deaminase | 0.117722 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0419704 | 0 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Brugia malayi | adenosine monophosphate deaminase | 0.117722 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.117722 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 0.5 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.59 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC50 (functional) | = 0.59 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.06 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.06 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 18281929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.