Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 0.1498 | 0.5784 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0173 | 0.0408 | 0.1482 |
Mycobacterium leprae | Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin | 0.1944 | 0.7598 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0408 | 0.0408 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0679 | 0.246 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0173 | 0.0408 | 0.0408 |
Toxoplasma gondii | dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0173 | 0.0408 | 0.6007 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0173 | 0.0408 | 0.6007 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0173 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0173 | 0.0408 | 0.0408 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 0.1944 | 0.7598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2536 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.1427 | 0.55 | 0.55 |
Echinococcus multilocularis | serotonin transporter | 0.0173 | 0.0408 | 0.166 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2536 | 1 | 1 |
Onchocerca volvulus | 0.0135 | 0.0253 | 0.6205 | |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0752 | 0.2756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.1296 | 0.4967 | 0.4967 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.0447 | 0.1518 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0173 | 0.0408 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.024 | 0.068 | 1 |
Onchocerca volvulus | 0.0173 | 0.0408 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 29.1 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 29.1 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 34 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 34 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 1655 nM | Inhibition of [3H]-Citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 2180 nM | Inhibition of [3H]-Citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.