Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hypothetical protein | 0.0752 | 0.2756 | 1 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1296 | 0.4967 | 0.4967 |
Schistosoma mansoni | amine GPCR | 0.024 | 0.068 | 1 |
Onchocerca volvulus | 0.0173 | 0.0408 | 1 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0173 | 0.0408 | 0.5 |
Brugia malayi | Serotonin receptor | 0.1427 | 0.55 | 0.55 |
Echinococcus multilocularis | serotonin transporter | 0.0173 | 0.0408 | 0.166 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2536 | 1 | 1 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 0.1944 | 0.7598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2536 | 1 | 1 |
Onchocerca volvulus | 0.0135 | 0.0253 | 0.6205 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0173 | 0.0408 | 0.0408 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0173 | 0.0408 | 0.6007 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0173 | 0.0408 | 0.0408 |
Echinococcus granulosus | serotonin transporter | 0.0173 | 0.0408 | 0.1482 |
Mycobacterium leprae | Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin | 0.1944 | 0.7598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 0.1498 | 0.5784 | 0.5 |
Toxoplasma gondii | dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0173 | 0.0408 | 0.0408 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0679 | 0.246 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0173 | 0.0408 | 0.6007 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0408 | 0.0408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 193 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 193 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 286 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 286 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 7795 nM | Inhibition of [3H]-Citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | > 10000 nM | Inhibition of [3H]-Citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.