Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor necrosis factor receptor superfamily, member 1A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.1897 | 0.5 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0053 | 1 | 1 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0053 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1897 | 0.1032 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1897 | 0.5 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1897 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1897 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1897 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1897 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.1897 | 0.1032 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1897 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.1897 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.1897 | 0.1032 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1897 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1897 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.1897 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1897 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1897 | 0.1032 |
Onchocerca volvulus | Netrin receptor homolog | 0.0035 | 0.0965 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0053 | 1 | 1 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0053 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1897 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.78 | Calculated partition coefficient (clogP) | ChEMBL. | 15006393 |
IC50 (functional) | = 1 uM | Inhibition of TNF-alpha-induced VCAM-1 expression | ChEMBL. | 15006393 |
IC50 (functional) | = 1 uM | Inhibition of TNF-alpha-induced VCAM-1 expression | ChEMBL. | 15006393 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.