Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0496 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0496 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0496 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0496 | 1 | 1 |
Onchocerca volvulus | 0.0496 | 1 | 1 | |
Echinococcus granulosus | hexokinase type 2 | 0.0496 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0496 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0496 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.271 | 0.0123 |
Toxoplasma gondii | hexokinase | 0.0496 | 1 | 0.5 |
Onchocerca volvulus | 0.0496 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.271 | 0.0123 |
Echinococcus multilocularis | hexokinase type 2 | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0311 | 0.6017 | 0.4604 |
Brugia malayi | Hexokinase family protein | 0.0311 | 0.6017 | 0.4604 |
Echinococcus multilocularis | hexokinase | 0.0496 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.0496 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0496 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0496 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0496 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0496 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.6602 | 0.5396 |
Schistosoma mansoni | hexokinase | 0.0496 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0158 | 0.271 | 0.0123 |
Trypanosoma cruzi | hexokinase, putative | 0.0496 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0496 | 1 | 1 |
Onchocerca volvulus | 0.0496 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0496 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0496 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0496 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0496 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0496 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0496 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Functional NMDA antagonist activity was confirmed in vivo in mice (intraperitoneally) using an NMDA-induced lethality assay; NT = Not tested | ChEMBL. | 11334562 |
ED50 (functional) | = 2.58 mg kg-1 | Functional NMDA antagonist activity was confirmed in vivo in mice (intraperitoneally) using an NMDA-induced lethality assay | ChEMBL. | 11334562 |
ED50 (functional) | = 2.58 mg kg-1 | Functional NMDA antagonist activity was confirmed in vivo in mice (intraperitoneally) using an NMDA-induced lethality assay | ChEMBL. | 11334562 |
IC50 (binding) | uM | Affinity for the NMDA receptor site was assessed by its ability to displace [3H]-TCP from its binding site in rat brain; NT = Not tested | ChEMBL. | 11334562 |
IC50 (binding) | 0 uM | Affinity for the NMDA receptor site was assessed by its ability to displace [3H]-TCP from its binding site in rat brain; NT = Not tested | ChEMBL. | 11334562 |
IC50 (binding) | = 0.018 uM | Displacement of [3H]-CPP from rat synaptic membrane glutamate NMDA receptor | ChEMBL. | 11334562 |
IC50 (binding) | = 0.018 uM | Displacement of [3H]-CPP from rat synaptic membrane glutamate NMDA receptor | ChEMBL. | 11334562 |
IC50 (binding) | = 1 uM | Displacement of [3H]-CPP from rat synaptic membrane glutamate NMDA receptor | ChEMBL. | 11334562 |
IC50 (binding) | = 1 uM | Displacement of [3H]-CPP from rat synaptic membrane glutamate NMDA receptor | ChEMBL. | 11334562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.