Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 467 aa | 25.1 % | |
Loa Loa (eye worm) | TYRA-2 protein | Adrenergic receptor alpha-2 | 450 aa | 488 aa | 23.8 % |
Schistosoma mansoni | amine GPCR | Adrenergic receptor alpha-2 | 450 aa | 439 aa | 29.2 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Adrenergic receptor alpha-2 | 450 aa | 423 aa | 31.7 % |
Echinococcus multilocularis | fmrfamide receptor | Adrenergic receptor alpha-2 | 450 aa | 366 aa | 19.9 % |
Echinococcus multilocularis | neuropeptides capa receptor | Adrenergic receptor alpha-2 | 450 aa | 486 aa | 20.6 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Adrenergic receptor alpha-2 | 450 aa | 473 aa | 24.1 % |
Echinococcus multilocularis | serotonin receptor | Adrenergic receptor alpha-2 | 450 aa | 426 aa | 31.9 % |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 478 aa | 20.7 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Adrenergic receptor alpha-2 | 450 aa | 476 aa | 21.0 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adrenergic receptor alpha-2 | 450 aa | 433 aa | 27.9 % |
Onchocerca volvulus | Adrenergic receptor alpha-2 | 450 aa | 420 aa | 19.8 % | |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Adrenergic receptor alpha-2 | 450 aa | 378 aa | 20.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0087 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0087 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0087 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0087 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0087 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0087 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.8 mg kg-1 | Antagonistic activity against clonidine-induced antinociception in mouse after po administration | ChEMBL. | 2887657 |
ED50 (functional) | = 3.8 mg kg-1 | Antagonistic activity against clonidine-induced antinociception in mouse after po administration | ChEMBL. | 2887657 |
Kd (functional) | = 8.03 | Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin | ChEMBL. | 2887657 |
Ki (binding) | = 13.8 nM | Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]-clonidine from rat brain cortical membranes | ChEMBL. | 2887657 |
Ki (binding) | = 13.8 nM | Binding affinity against alpha-2 adrenergic receptor was determined by the displacement of [3H]-clonidine from rat brain cortical membranes | ChEMBL. | 2887657 |
pA2 (functional) | = 8.03 | Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin | ChEMBL. | 2887657 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.