Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0051 | 0.0067 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0051 | 0.0067 | 0.0067 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0051 | 0.0067 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.1003 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0051 | 0.0067 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 7 | 0.0091 | 0.1709 | 0.9298 |
Echinococcus granulosus | cyclin | 0.0094 | 0.1833 | 1 |
Loa Loa (eye worm) | cyclin C | 0.0094 | 0.1833 | 0.1833 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.0067 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0051 | 0.0067 | 0.5 |
Brugia malayi | Cyclin C | 0.0094 | 0.1833 | 0.1778 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0051 | 0.0067 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK7 protein kinase | 0.0091 | 0.1709 | 0.1709 |
Echinococcus multilocularis | cyclin dependent kinase 7 | 0.0091 | 0.1709 | 0.9298 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0168 | 0.4906 | 0.4871 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0168 | 0.4906 | 0.4906 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.0067 | 0.0067 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0051 | 0.0067 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0051 | 0.0067 | 0.0067 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0094 | 0.1833 | 1 |
Brugia malayi | cyclin-dependent kinase 7 homolog | 0.0091 | 0.1709 | 0.1653 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.0067 | 0.5 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0094 | 0.1833 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0051 | 0.0067 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.1709 | 0.9298 |
Plasmodium falciparum | protein kinase 5 | 0.0051 | 0.0067 | 0.5 |
Plasmodium vivax | protein kinase Crk2 | 0.0051 | 0.0067 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0051 | 0.0067 | 0.5 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0094 | 0.1833 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.029 | 1 | 1 |
Echinococcus multilocularis | cyclin | 0.0094 | 0.1833 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0051 | 0.0067 | 0.5 |
Trichomonas vaginalis | cyclin H, putative | 0.0074 | 0.1003 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0091 | 0.1709 | 0.9298 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.