Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | No references | |
Homo sapiens | arachidonate 5-lipoxygenase-activating protein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 1 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.0135 | 0.8299 | 0.5 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0135 | 0.8299 | 0.8299 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0135 | 0.8299 | 0.8299 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 8 nM | In vitro inhibition of LTB4 biosynthesis in Ca++ ionophore activated human polymorphonuclear(HPMN) leukocytes. | ChEMBL. | 10476875 |
IC50 (functional) | = 8 nM | In vitro inhibition of LTB4 biosynthesis in Ca++ ionophore activated human polymorphonuclear(HPMN) leukocytes. | ChEMBL. | 10476875 |
IC50 (binding) | = 59 nM | Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand. | ChEMBL. | 10476875 |
IC50 (binding) | = 59 nM | Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand. | ChEMBL. | 10476875 |
IC50 (functional) | > 3000 nM | The drug dependent inhibition of LTB4 biosynthesis in human whole blood (HWB) activated with the ionophore A-23,187 | ChEMBL. | 10476875 |
IC50 (functional) | > 3000 nM | The drug dependent inhibition of LTB4 biosynthesis in human whole blood (HWB) activated with the ionophore A-23,187 | ChEMBL. | 10476875 |
IC50 (functional) | = 1.09 uM | Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay | ChEMBL. | No reference |
IC50 (functional) | = 1.09 uM | Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassay | ChEMBL. | No reference |
IC50 (functional) | = 17 uM | Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils | ChEMBL. | No reference |
IC50 (functional) | = 17 uM | Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | Compound was tested in vivo against rat anaphylaxis in the peritoneal cavity at concentration of 100 micromol/kg | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10476875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.