Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0525 | 0.0525 |
Leishmania major | hypothetical protein, conserved | 0.0151 | 0.0525 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0525 | 0.0525 |
Toxoplasma gondii | kringle domain-containing protein | 0.0151 | 0.0525 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0151 | 0.0525 | 0.0525 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0151 | 0.0525 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0151 | 0.0525 | 0.0525 |
Echinococcus granulosus | protein will die slowly | 0.0811 | 1 | 1 |
Onchocerca volvulus | 0.0811 | 1 | 1 | |
Loa Loa (eye worm) | WD40 repeat protein | 0.0811 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0151 | 0.0525 | 0.0525 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0811 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0811 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0151 | 0.0525 | 0.0525 |
Echinococcus multilocularis | protein will die slowly | 0.0811 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0151 | 0.0525 | 0.0525 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0151 | 0.0525 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0151 | 0.0525 | 0.5 |
Onchocerca volvulus | 0.0151 | 0.0525 | 0.0525 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (binding) | = 5 | Binding affinity for Cholecystokinin type A receptor in Guinea-Pig gall bladder | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.