Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | transfer RNA-Lys | 0.008 | 0.1342 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.01 | 0.1945 | 0.9468 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0173 | 0.4167 | 0.4167 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.109 | 0.109 |
Brugia malayi | bHLH-PAS transcription factor | 0.008 | 0.1342 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | single minded 2 | 0.008 | 0.1342 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0072 | 0.109 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0103 | 0.2038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Onchocerca volvulus | 0.0177 | 0.4307 | 1 | |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0103 | 0.2038 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0073 | 0.1114 | 0.1368 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0067 | 0.0929 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0079 | 0.1303 | 0.0309 |
Echinococcus granulosus | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0103 | 0.2038 | 0.1594 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0073 | 0.1114 | 0.155 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0103 | 0.2038 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0091 | 0.1663 | 0.1198 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0079 | 0.1303 | 0.0309 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.109 | 0.0838 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0194 | 0.4809 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Echinococcus multilocularis | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.109 | 0.0593 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0103 | 0.2038 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0194 | 0.4809 | 0.6391 |
Schistosoma mansoni | single-minded | 0.0108 | 0.2203 | 0.2499 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0054 | 0.0529 | 0.0529 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0073 | 0.1114 | 0.0625 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Mycobacterium ulcerans | putative regulatory protein | 0.008 | 0.1342 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0067 | 0.0929 | 0.0936 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0054 | 0.0529 | 0.0529 |
Toxoplasma gondii | ribonuclease HI protein | 0.0073 | 0.1114 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Leishmania major | ribonuclease H1, putative | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0103 | 0.2038 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0082 | 0.1395 | 0.633 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4384 | 0.4384 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0054 | 0.0529 | 0.0529 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0108 | 0.2203 | 0.2499 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | RNA helicase, putative | 0.0273 | 0.7226 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0079 | 0.1303 | 0.0309 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0079 | 0.1303 | 0.0309 |
Echinococcus multilocularis | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Onchocerca volvulus | 0.008 | 0.1342 | 0.2153 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0067 | 0.0929 | 0.0936 |
Echinococcus granulosus | carboxylesterase 5A | 0.0072 | 0.109 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | ribonuclease H1 | 0.0073 | 0.1114 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0335 | 0.9139 | 0.9139 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0103 | 0.2038 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0079 | 0.1303 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.7226 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.109 | 0.0593 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0194 | 0.4809 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0335 | 0.9139 | 0.9091 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Giardia lamblia | Ribonuclease H | 0.0073 | 0.1114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Brugia malayi | Protein-tyrosine phosphatase | 0.019 | 0.4711 | 0.4416 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.1395 | 0.633 |
Brugia malayi | PAS domain containing protein | 0.0108 | 0.2203 | 0.1767 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0054 | 0.0529 | 0.0529 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Affinity constant (binding) | = 0.00004 uM | In vitro affinity constant against beta-2 adrenergic receptor from guinea pig trachea | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.00004 uM | In vitro affinity constant against beta-2 adrenergic receptor from guinea pig trachea | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.055 uM | In vitro affinity constant against beta-1 adrenergic receptor from guinea pig artia | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.055 uM | In vitro affinity constant against beta-1 adrenergic receptor from guinea pig artia | ChEMBL. | 6138434 |
ED50 (binding) | = 16 ug kg-1 | Beta-2 adrenergic receptor blockade measured as inhibition of depressor response caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
ED50 (binding) | = 16 ug kg-1 | Beta-2 adrenergic receptor blockade measured as inhibition of depressor response caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
ED50 (functional) | = 29 ug kg-1 | Beta-1 adrenergic receptor blockade measured as inhibition of tachycardia caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
ED50 (functional) | = 29 ug kg-1 | Beta-1 adrenergic receptor blockade measured as inhibition of tachycardia caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
Ratio (binding) | = 0.00073 | Ratio of Beta-2(trachea) to Beta-1(Atria) adrenoceptor affinity constants from guinea pig | ChEMBL. | 6138434 |
Ratio (functional) | = 0.55 | Ratio of rat Beta-2 to Beta-1 adrenoceptor antagonism | ChEMBL. | 6138434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.