Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Echinococcus granulosus | cathepsin b | 0.0146 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0055 | 0.1881 | 0.1881 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Schistosoma mansoni | egf-like domain protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0054 | 0.1752 | 0.1752 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Echinococcus multilocularis | cathepsin b | 0.0146 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1323 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0146 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0049 | 0.1323 | 0.1323 |
Echinococcus multilocularis | cathepsin b | 0.0146 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | fibroinase | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0055 | 0.1881 | 0.1881 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0055 | 0.1881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0042 | 0.0688 | 0.0688 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0054 | 0.1752 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0049 | 0.1323 | 0.7035 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1323 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Echinococcus granulosus | Tolloid protein 1 | 0.0042 | 0.0688 | 0.0688 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0054 | 0.1752 | 0.1752 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Onchocerca volvulus | 0.0055 | 0.1881 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1323 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Entamoeba histolytica | cysteine protease, putative | 0.0049 | 0.1323 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1881 | 0.1881 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0049 | 0.1323 | 0.1323 |
Onchocerca volvulus | Arrow homolog | 0.0042 | 0.0688 | 0.3659 |
Loa Loa (eye worm) | cysteine protease | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Echinococcus granulosus | cathepsin l1 | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Toxoplasma gondii | kringle domain-containing protein | 0.0055 | 0.1881 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1323 | 0.7035 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0042 | 0.0688 | 0.0688 |
Toxoplasma gondii | cathepsin CPL | 0.0049 | 0.1323 | 0.5323 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0042 | 0.0688 | 0.0688 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0049 | 0.1323 | 0.1323 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.0682 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.1881 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0055 | 0.1881 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Toxoplasma gondii | cathepsin B | 0.0054 | 0.1752 | 0.8922 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0054 | 0.1752 | 0.7695 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | ctsf protein | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0146 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0042 | 0.0688 | 0.0688 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0054 | 0.1752 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 0.1881 | 0.1881 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | cathepsin B | 0.0054 | 0.1752 | 0.1752 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0049 | 0.1323 | 0.1323 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.0682 |
Brugia malayi | Kringle domain containing protein | 0.0055 | 0.1881 | 0.1881 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0055 | 0.1881 | 0.1881 |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1323 | 0.7035 |
Brugia malayi | Fibulin-1 precursor | 0.0042 | 0.0688 | 0.0688 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0055 | 0.1881 | 0.1281 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1881 | 0.1881 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 8.79 | Partition coefficient (logP) | ChEMBL. | 11334564 |
Ratio (functional) | = 2.19 | Tumor and skin uptake ratio of the compound | ChEMBL. | 11334564 |
Skin uptake (functional) | = 6.29 uM | Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Skin uptake (functional) | = 6.29 uM | Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Tumor uptake (functional) | = 13.8 uM | Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Tumor uptake (functional) | = 13.8 uM | Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.