Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1296 | 0.4967 | 0.4967 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0752 | 0.2756 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0173 | 0.0408 | 0.5 |
Onchocerca volvulus | 0.0173 | 0.0408 | 1 | |
Schistosoma mansoni | amine GPCR | 0.024 | 0.068 | 1 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 0.1944 | 0.7598 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2536 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2536 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0173 | 0.0408 | 0.166 |
Brugia malayi | Serotonin receptor | 0.1427 | 0.55 | 0.55 |
Onchocerca volvulus | 0.0135 | 0.0253 | 0.6205 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0173 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0173 | 0.0408 | 0.0408 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0173 | 0.0408 | 0.6007 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2536 | 1 | 1 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 0.1498 | 0.5784 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0408 | 0.0408 |
Mycobacterium leprae | Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin | 0.1944 | 0.7598 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0173 | 0.0408 | 0.1482 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0408 | 0.0408 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0173 | 0.0408 | 0.6007 |
Toxoplasma gondii | dihydropteroate synthase | 0.0447 | 0.1518 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0173 | 0.0408 | 0.0408 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0679 | 0.246 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | = 17 nM | Inhibition of [3H]-WIN- 35,428 Binding to theDopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
IC50 (binding) | > 10000 nM | Inhibition of [3H]-Citalopram Binding to the Serotonin Transporter in Rhesus (Macaca mulatta) or Cynomolgus Monkey (Macaca fascicularis) Caudate-Putamen | ChEMBL. | 12672255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.