Detailed information for compound 551043

Basic information

Technical information
  • TDR Targets ID: 551043
  • Name: N-hydroxynitramide
  • MW: 78.0275 | Formula: H2N2O3
  • H donors: 2 H acceptors: 3 LogP: 0.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)NO
  • InChi: 1S/H2N2O3/c3-1-2(4)5/h1,3H
  • InChiKey: BUIMWOLDCCGZKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • oxyhyponitrite
  • 18550-55-5
  • Hyponitric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0685
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0091 0.5
Mycobacterium tuberculosis Probable reductase 0.0195 0.2238 0.8837
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0091 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0351
Brugia malayi hypothetical protein 0.0051 0.0362 0.076
Trypanosoma brucei trypanothione reductase 0.0086 0.0816 1
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0685
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0362 0.3737
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0886 0.2425
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0091 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0816 1
Schistosoma mansoni hypothetical protein 0.0166 0.1857 0.571
Brugia malayi TAR-binding protein 0.0125 0.1319 0.3446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0312
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1296 0.3338
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0195 0.2238 0.8837
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1319 0.4055
Mycobacterium tuberculosis Probable oxidoreductase 0.0217 0.2521 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0242 0.0362
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0351
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0816 0.1982
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0114 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0195 0.2238 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0822 0.0822
Toxoplasma gondii thioredoxin reductase 0.0086 0.0816 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0956 0.2377
Schistosoma mansoni hypothetical protein 0.0068 0.0588 0.1807
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0956 0.2427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0642 0.1756
Schistosoma mansoni hypothetical protein 0.0166 0.1857 0.571
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1319 0.3403
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1319 0.4055
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0956 0.0956
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0114
Brugia malayi hypothetical protein 0.0033 0.0129 0.0108
Loa Loa (eye worm) hypothetical protein 0.01 0.0996 0.2491
Echinococcus multilocularis protein patched 0.0041 0.0242 0.0242
Echinococcus multilocularis expressed conserved protein 0.0091 0.088 0.088
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0362 0.3737
Loa Loa (eye worm) RNA binding protein 0.0125 0.1319 0.3403
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0091 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0886 0.2725
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0351
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0091 0.5
Echinococcus granulosus expressed conserved protein 0.0091 0.088 0.2407
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0114
Plasmodium falciparum thioredoxin reductase 0.0086 0.0816 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0091 0.0091
Brugia malayi Thioredoxin reductase 0.0086 0.0816 0.2035
Echinococcus granulosus GPCR family 2 0.0032 0.0114 0.0312
Treponema pallidum NADH oxidase 0.003 0.0091 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0886 0.2181
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0217 0.2521 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0312
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0956 0.2615
Echinococcus granulosus zinc finger transcription factor gli2 0.0305 0.3655 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.0362
Leishmania major hypothetical protein, conserved 0.0051 0.0362 0.3737
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0886 0.0886
Loa Loa (eye worm) zinc finger protein 0.0305 0.3655 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0362 0.0699
Echinococcus granulosus tar DNA binding protein 0.0125 0.1319 0.3609
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0996 0.254
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0091 0.0278
Schistosoma mansoni hypothetical protein 0.004 0.0223 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0886 0.2725
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0242 0.0663
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0195 0.2238 0.8837
Echinococcus multilocularis geminin 0.0166 0.1857 0.1857
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0886 0.2232
Echinococcus multilocularis zinc finger transcription factor gli2 0.0305 0.3655 0.3655
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1319 0.3446
Loa Loa (eye worm) hypothetical protein 0.0051 0.0363 0.0703
Plasmodium vivax glutathione reductase, putative 0.0086 0.0816 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0362 0.3737
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1319 0.3403
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1492 0.4082
Loa Loa (eye worm) glutathione reductase 0.0086 0.0816 0.1982
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0091 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0362 0.3737
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0996 0.254
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0242 0.0663
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1319 0.1319
Echinococcus multilocularis protein dispatched 1 0.0047 0.0318 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1319 0.4055
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0362 0.3737
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1296 0.3338
Brugia malayi Zinc finger, C2H2 type family protein 0.0305 0.3655 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0091 0.5
Plasmodium falciparum glutathione reductase 0.0086 0.0816 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0217 0.2521 1
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0816 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0956 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0195 0.2238 0.8837
Schistosoma mansoni patched 1 0.0041 0.0242 0.0745
Echinococcus multilocularis GPCR, family 2 0.0032 0.0114 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0886 0.2425
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0362 0.3737
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0642 0.1973
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1319 0.4055
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0091 0.5
Brugia malayi MH2 domain containing protein 0.0123 0.1296 0.3382
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0588 0.1395
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0996 0.2491
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0822 0.225
Brugia malayi glutathione reductase 0.0086 0.0816 0.2035
Brugia malayi hypothetical protein 0.0072 0.0642 0.1547
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0642 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0242 1
Echinococcus granulosus geminin 0.0166 0.1857 0.5081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0975 0.2998
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0886 0.0886
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0195 0.2238 0.8837
Leishmania major trypanothione reductase 0.0086 0.0816 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0362 0.3737
Brugia malayi RNA binding protein 0.0125 0.1319 0.3446
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0816 0.2985
Brugia malayi CHE-14 protein 0.0041 0.0242 0.0426
Loa Loa (eye worm) hypothetical protein 0.0068 0.0588 0.1338
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1492 0.1492
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0114 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1319 0.4055
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0217 0.2521 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0886 0.2725
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0351
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0242 0.0242
Schistosoma mansoni hypothetical protein 0.0072 0.0642 0.1973

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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