TDR Targets

Basic information

Technical information

TDR Targets ID: 551187
Name: quinoline-8-sulfonyl chloride
MW: 227.667 | Formula: C9H6ClNO2S
H donors: 0 H acceptors: 3 LogP: 2.21 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: ClS(=O)(=O)c1cccc2c1nccc2
InChi: 1S/C9H6ClNO2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H
InChiKey: JUYUYCIJACTHMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-quinolinesulfonyl chloride
18704-37-5
22695_FLUKA
FS000331
CC 04303
5-22-07-00567 (Beilstein Handbook Reference)
8-Chlorosulfonyl-1-benzazine
8-Quinolylsulfonyl chloride
BRN 0156347
EINECS 242-515-5
NSC 91506
Quinoline-8-sulfonic acid chloride
Quinoline-8-sulphonyl chloride
NSC91506
Q1506_ALDRICH

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	inositol-1	0.0037	0.0538	0.1071
Onchocerca volvulus		0.0036	0.0493	0.5
Toxoplasma gondii	ABC1 family protein	0.0036	0.0493	0.1843
Loa Loa (eye worm)	hypothetical protein	0.005	0.1171	0.233
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.1314	0.1811
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.5028	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1036	0.1198
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0493	0.098
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0081	0.2673	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0493	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0493	0.9153
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0538	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0088	0.0328
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0538	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0493	0.0149
Brugia malayi	beta-lactamase	0.0036	0.0493	0.098
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0493	0.0149
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.5028	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0538	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0398	0.0792
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0538	1
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.5028	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0493	0.098
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0493	0.0149
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1171	0.233
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0493	0.1843
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0538	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0493	0.098
Onchocerca volvulus		0.0036	0.0493	0.5
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0493	0.0149
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1036	0.1198
Brugia malayi	TAR-binding protein	0.0129	0.5028	1
Brugia malayi	Inositol-1	0.0037	0.0538	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0081	0.2673	0.5317
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0493	0.0149
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0493	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0493	0.9153
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0538	0.0302
Brugia malayi	Probable ClpP-like protease	0.0081	0.2673	0.5317
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.1314	0.1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0493	0.0149
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0088	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Schistosoma mansoni	peptidase Clp (S14 family)	0.0081	0.2673	0.4914
Toxoplasma gondii	hypothetical protein	0.0028	0.0088	0.0328
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1036	0.1198
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Loa Loa (eye worm)	RNA binding protein	0.0129	0.5028	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0538	0.5
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.2673	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1036	0.206
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0493	0.0149
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1036	0.1198
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0398	0.0792
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0081	0.2673	1
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.5028	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.5028	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0538	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0493	0.0204
Onchocerca volvulus		0.0036	0.0493	0.5
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0538	0.0302
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1036	0.206
Brugia malayi	beta-lactamase family protein	0.0036	0.0493	0.098
Echinococcus granulosus	tar DNA binding protein	0.0129	0.5028	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0081	0.2673	0.4808
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0493	0.9153
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.5028	1
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0538	0.0209
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.1314	0.1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0493	0.0149
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0493	0.9153
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.1314	0.1811
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0081	0.2673	0.4808
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1171	0.233
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.5028	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1036	0.1377
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.2673	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0349	0.101
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0538	0.0101
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0538	0.0101
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0493	0.1567
Brugia malayi	beta-lactamase family protein	0.0036	0.0493	0.098
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1171	0.233
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1036	0.1377
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0493	0.1567
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0493	0.0204
Brugia malayi	RNA binding protein	0.0129	0.5028	1
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.5028	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0081	0.2673	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0493	0.098
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.1314	0.4744
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0538	0.2014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1036	0.1377
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.5028	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 29220

Bibliographic References

No literature references available for this target.

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Detailed information for compound 551187