Detailed information for compound 551951

Basic information

Technical information
  • TDR Targets ID: 551951
  • Name: 3-methylpyridin-4-amine
  • MW: 108.141 | Formula: C6H8N2
  • H donors: 1 H acceptors: 1 LogP: 0.54 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnccc1N
  • InChi: 1S/C6H8N2/c1-5-4-8-3-2-6(5)7/h2-4H,1H3,(H2,7,8)
  • InChiKey: VGJLGPCXUGIXRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-4-pyridinamine
  • (3-methyl-4-pyridyl)amine
  • 3-methyl-4-aminopyridine
  • 1990-90-5
  • EINECS 217-872-5
  • 5-22-09-00286 (Beilstein Handbook Reference)
  • 4-Pyridinamine, 3-methyl- (9CI)
  • STK206059
  • 3-methyl-4-pyridinylamine
  • AC-907/34117051
  • BRN 0107957
  • 3-Picoline, 4-amino-
  • 4-Amino-3-methylpyridine
  • 4-Pyridinamine, 3-methyl-
  • NSC52454
  • Philips 1908
  • Phillips 1908
  • WLN: T6NJ C1 DZ
  • NSC 52454
  • 4-Amino-3-picoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0724 0.0724
Echinococcus multilocularis protein patched 0.0041 0.2121 0.2121
Chlamydia trachomatis SWIB complex protein 0.0024 0.0724 0.5
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0024 0.0724 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0388 0.5
Brugia malayi brahma associated protein 60 kDa 0.0024 0.0724 0.1093
Echinococcus granulosus tar DNA binding protein 0.0062 0.3801 0.3801
Schistosoma mansoni ap endonuclease 0.002 0.0388 0.0575
Schistosoma mansoni hypothetical protein 0.0024 0.0724 0.1074
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0024 0.0724 0.1093
Brugia malayi intermediate filament protein 0.0029 0.1103 0.1666
Loa Loa (eye worm) hypothetical protein 0.0051 0.2882 0.4354
Echinococcus granulosus expressed conserved protein 0.0091 0.6141 0.6141
Brugia malayi hypothetical protein 0.0035 0.1595 0.2409
Brugia malayi TAR-binding protein 0.0062 0.3801 0.5743
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0388 0.0586
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.6619 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.1103 0.1666
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1595 0.1595
Schistosoma mansoni lamin 0.0029 0.1103 0.1636
Schistosoma mansoni hypothetical protein 0.0024 0.0724 0.1074
Echinococcus multilocularis protein dispatched 1 0.0047 0.2599 0.2599
Loa Loa (eye worm) hypothetical protein 0.0033 0.1463 0.221
Loa Loa (eye worm) hypothetical protein 0.0028 0.106 0.1601
Schistosoma mansoni hypothetical protein 0.004 0.1999 0.2966
Onchocerca volvulus 0.0029 0.1103 1
Schistosoma mansoni hypothetical protein 0.0033 0.1463 0.217
Echinococcus granulosus lamin 0.0029 0.1103 0.1103
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0724 0.0724
Schistosoma mansoni patched 1 0.0041 0.2121 0.3146
Echinococcus granulosus SWI:SNF matrix associated 0.0024 0.0724 0.0724
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.6741 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.3801 0.5743
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0724 0.1938
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3801 0.5639
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0388 0.5
Loa Loa (eye worm) TAR-binding protein 0.0062 0.3801 0.5743
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0388 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0388 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.2121 0.3204
Echinococcus multilocularis tar DNA binding protein 0.0062 0.3801 0.3801
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.2723 0.4114
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 1 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.1103 0.1636
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0006 0.0009
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0035 0.1595 0.2366
Echinococcus multilocularis musashi 0.0029 0.1103 0.1103
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1595 0.1595
Schistosoma mansoni lamin 0.0029 0.1103 0.1636
Loa Loa (eye worm) hypothetical protein 0.0086 0.5732 0.866
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1595 0.2366
Schistosoma mansoni eyes absent homolog 0.0086 0.5732 0.8504
Brugia malayi SWIB/MDM2 domain containing protein 0.0024 0.0724 0.1093
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0024 0.0724 0.0724
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.2723 0.4114
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.2121 1
Onchocerca volvulus 0.0029 0.1103 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0388 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.1103 0.1666
Schistosoma mansoni hypothetical protein 0.0024 0.0724 0.1074
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0724 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.2121 0.3204
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.3801 0.5743
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.6619 0.6619
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.2121 0.2121
Echinococcus granulosus intermediate filament protein 0.0029 0.1103 0.1103
Entamoeba histolytica hypothetical protein 0.0035 0.1595 0.1937
Echinococcus multilocularis lamin 0.0029 0.1103 0.1103
Schistosoma mansoni hypothetical protein 0.004 0.1999 0.2966
Schistosoma mansoni brg-1 associated factor 0.0024 0.0724 0.1074
Schistosoma mansoni ap endonuclease 0.002 0.0388 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3801 0.5639
Brugia malayi hypothetical protein 0.0086 0.5732 0.866
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0388 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.1595 0.1937
Loa Loa (eye worm) intermediate filament protein 0.0029 0.1103 0.1666
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0388 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0388 0.5
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0049 0.2723 0.4114
Echinococcus multilocularis SWI:SNF matrix associated 0.0024 0.0724 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3801 0.5639
Brugia malayi RNA binding protein 0.0062 0.3801 0.5743
Brugia malayi CHE-14 protein 0.0041 0.2121 0.3204
Loa Loa (eye worm) hypothetical protein 0.0097 0.6619 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0388 0.0586
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0388 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.6619 1
Schistosoma mansoni hypothetical protein 0.004 0.1999 0.2966
Chlamydia trachomatis DNA topoisomerase I 0.0024 0.0724 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.6619 0.6619
Echinococcus granulosus Protein patched homolog 1 0.0041 0.2121 0.2121
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0024 0.0724 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0388 0.0388
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1463 0.221
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3801 0.5639
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0388 0.0388
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0024 0.0724 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0062 0.3801 0.5639
Loa Loa (eye worm) brahma associated protein 0.0024 0.0724 0.1093
Entamoeba histolytica hypothetical protein 0.0035 0.1595 0.1937
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0024 0.0724 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1103 0.1666
Brugia malayi brahma associated protein 60 kDa 0.0024 0.0724 0.1093
Echinococcus granulosus lamin dm0 0.0029 0.1103 0.1103
Schistosoma mansoni hypothetical protein 0.004 0.1999 0.2966
Echinococcus multilocularis lamin dm0 0.0029 0.1103 0.1103
Loa Loa (eye worm) hypothetical protein 0.0086 0.5732 0.866
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.2723 0.4114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.3801 0.5743
Echinococcus multilocularis expressed conserved protein 0.0091 0.6141 0.6141
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0024 0.0724 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0024 0.0724 1
Entamoeba histolytica hypothetical protein 0.0035 0.1595 0.1937

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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