Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.4151 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.4151 | 0.5 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.4151 | 0.4151 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.4151 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.3482 |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.4151 | 0.4151 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.4151 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.4151 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.4151 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.4151 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | lamin | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.