Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.150623 | 0.753721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.150623 | 0.753721 | 0.752205 |
Brugia malayi | Protein kinase domain containing protein | 0.196834 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.013973 | 0.0254443 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0200335 | 0.0577439 | 0.0766117 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0478696 | 0.206097 | 0.273439 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.013973 | 0.0254443 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0200335 | 0.0577439 | 0.0766117 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0478696 | 0.206097 | 0.213157 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0478696 | 0.206097 | 0.213157 |
Toxoplasma gondii | hypothetical protein | 0.150623 | 0.753721 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.013973 | 0.0254443 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.013973 | 0.0254443 | 0.5 |
Onchocerca volvulus | 0.150623 | 0.753721 | 1 | |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.1967 | 0.999288 | 1 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.150623 | 0.753721 | 0.747291 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.013973 | 0.0254443 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199514 | 0.0573064 | 0.0494694 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.150623 | 0.753721 | 1 |
Onchocerca volvulus | 0.150623 | 0.753721 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.150623 | 0.753721 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013973 | 0.0254443 | 0.0173182 |
Plasmodium falciparum | conserved protein, unknown function | 0.150623 | 0.753721 | 0.5 |
Brugia malayi | Amyloid A4 extracellular domain containing protein | 0.0253111 | 0.0858712 | 0.0620045 |
Loa Loa (eye worm) | hypothetical protein | 0.150623 | 0.753721 | 0.752205 |
Loa Loa (eye worm) | hypothetical protein | 0.175769 | 0.887738 | 0.887437 |
Loa Loa (eye worm) | hypothetical protein | 0.0200335 | 0.0577439 | 0.0499109 |
Brugia malayi | hypothetical protein | 0.0200335 | 0.0577439 | 0.0331428 |
Loa Loa (eye worm) | hypothetical protein | 0.0200335 | 0.0577439 | 0.0499109 |
Loa Loa (eye worm) | hypothetical protein | 0.0200335 | 0.0577439 | 0.0499109 |
Schistosoma mansoni | hypothetical protein | 0.150623 | 0.753721 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 0.784 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | = 0.784 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.0743 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.0743 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.12 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.12 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IC50 (functional) | = 2.44 uM | Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B and MTT assay | ChEMBL. | 22119124 |
IC50 (functional) | = 9.67 uM | Cytotoxicity against human HCT116 cells after 72 hrs by sulforhodamine B and MTT assay | ChEMBL. | 22119124 |
IC50 (functional) | > 10 uM | Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay | ChEMBL. | 22119124 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HT-29 cells | ChEMBL. | 24937209 |
IFI promiscuity index | = 0.1236 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Inhibition (binding) | Inhibition of human topoisomerase 2-mediated decatenation of kinetoplast DNA at 100 uM after 15 mins by agarose gel electrophoresis | ChEMBL. | 22119124 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 | |
Homo sapiens | ChEMBL23 | 22119124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.