Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.6997 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.6907 | 0.8601 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0363 | 0.0314 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0205 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0481 | 0.0179 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0028 | 0.0596 | 0.0309 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0205 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0205 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2427 | 0.2604 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0596 | 0.0309 |
Leishmania major | ribonuclease H1, putative | 0.0026 | 0.0481 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7953 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0363 | 0.0449 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2427 | 0.3111 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.4203 | 0.4981 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0205 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0363 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0026 | 0.0481 | 0.5 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0481 | 0.0179 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2427 | 0.2604 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0363 | 0.0314 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0363 | 0.0314 |
Brugia malayi | RNase H family protein | 0.0026 | 0.0481 | 0.0179 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0596 | 0.0309 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2427 | 0.2604 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6907 | 0.987 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0363 | 0.0449 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0028 | 0.0596 | 0.0309 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2427 | 0.3111 |
Trypanosoma brucei | RNA helicase, putative | 0.0096 | 0.4203 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0026 | 0.0481 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0363 | 0.5 |
Echinococcus granulosus | geminin | 0.0167 | 0.7953 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0363 | 0.0314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2427 | 0.2604 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2427 | 0.3421 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6907 | 0.987 |
Onchocerca volvulus | 0.0149 | 0.6997 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2427 | 0.2604 |
Trichomonas vaginalis | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.6907 | 0.8601 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2427 | 0.3421 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0363 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2427 | 0.3421 |
Brugia malayi | hypothetical protein | 0.0149 | 0.6997 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0028 | 0.0596 | 0.0309 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0363 | 0.0449 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0026 | 0.0481 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.7953 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.005 | 0.005 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.6907 | 0.8601 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2427 | 0.2604 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2427 | 0.3111 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0363 | 0.0314 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0026 | 0.0481 | 0.0179 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0363 | 0.0314 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0363 | 0.0314 |
Giardia lamblia | Ribonuclease H | 0.0026 | 0.0481 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0363 | 0.0314 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.6907 | 0.9864 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2427 | 0.2604 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.7953 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
14 literature references were collected for this gene.