Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tumor protein p63 | 0.0351 | 0.6972 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0185 | 0.2958 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0906 | 0.0781 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0185 | 0.2958 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0185 | 0.2958 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0185 | 0.2958 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0136 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0906 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0185 | 0.2958 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0906 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0185 | 0.2958 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0906 | 0.0781 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0185 | 0.2958 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0185 | 0.2958 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0351 | 0.6972 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0185 | 0.2958 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.