Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.4093 | 0.363 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0374 | 0.8999 | 0.8999 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0374 | 0.8999 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.4093 | 0.4093 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0374 | 0.8999 | 0.8999 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.4093 | 0.4093 |
Echinococcus granulosus | geminin | 0.0176 | 0.3584 | 0.3584 |
Trypanosoma cruzi | GMP reductase | 0.0374 | 0.8999 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0372 | 0.0372 |
Trypanosoma cruzi | GMP reductase | 0.0374 | 0.8999 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.4093 | 0.1199 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.4093 | 0.1199 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0176 | 0.3591 | 0.3591 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3584 | 0.3584 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0374 | 0.8999 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0374 | 0.8999 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.3584 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.3591 | 0.3591 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4093 | 0.363 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.3591 | 0.3591 |
Echinococcus granulosus | muscleblind protein | 0.0176 | 0.3591 | 0.3591 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0372 | 0.0372 |
Onchocerca volvulus | Putative GMP reductase | 0.0161 | 0.3172 | 0.7751 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0374 | 0.8999 | 1 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0364 | 0.8747 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0374 | 0.8999 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0268 | 0.6112 | 0.6112 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4093 | 0.4549 |
Brugia malayi | hypothetical protein | 0.0093 | 0.1297 | 0.1297 |
Brugia malayi | Muscleblind-like protein | 0.0176 | 0.3591 | 0.3591 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0372 | 0.0372 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0374 | 0.8999 | 0.8999 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0203 | 0.4335 | 0.1633 |
Onchocerca volvulus | 0.0195 | 0.4093 | 1 | |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0203 | 0.4335 | 0.3944 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0161 | 0.3172 | 0.3172 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.4093 | 0.4093 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0372 | 0.0372 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.041 | 1 | 1 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0364 | 0.8747 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.5308 | 0.5208 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.041 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.3584 | 0.4749 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0374 | 0.8999 | 0.8999 |
Schistosoma mansoni | high-affinity choline transporter | 0.041 | 1 | 1 |
Loa Loa (eye worm) | GMP reductase | 0.0161 | 0.3172 | 0.3172 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3843 | 0.5289 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0374 | 0.8999 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0374 | 0.8999 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Trypanosoma brucei | GMP reductase | 0.0374 | 0.8999 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0364 | 0.8747 | 0.9548 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0374 | 0.8999 | 0.8999 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0176 | 0.3584 | 0.8755 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0374 | 0.8999 | 1 |
Echinococcus multilocularis | geminin | 0.0176 | 0.3584 | 0.3584 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.6112 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0161 | 0.3172 | 0.3172 |
Echinococcus multilocularis | muscleblind protein | 0.0176 | 0.3591 | 0.3591 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.4093 | 0.4093 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.4093 | 0.4093 |
Brugia malayi | GMP reductase | 0.0161 | 0.3172 | 0.3172 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0374 | 0.8999 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.3843 | 0.5289 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0268 | 0.6112 | 0.6112 |
Toxoplasma gondii | IMP dehydrogenas | 0.0374 | 0.8999 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0374 | 0.8999 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.068 uM | Compound was tested in vitro for the inhibition of human thymidylate synthase (TS) | ChEMBL. | 1578484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.