Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | dopamine-beta-monooxygenase | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Schistosoma japonicum | ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0280242 | 0.731365 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.00914146 | 0.14007 | 0.191519 |
Brugia malayi | hypothetical protein | 0.0100246 | 0.167725 | 0.229331 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0280242 | 0.731365 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0257105 | 0.658914 | 0.872195 |
Echinococcus multilocularis | nischarin | 0.0103297 | 0.17728 | 0.0629291 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0280242 | 0.731365 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0257105 | 0.658914 | 0.872195 |
Brugia malayi | flavodoxin family protein | 0.0280242 | 0.731365 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0366029 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.00992078 | 0.164474 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0280242 | 0.731365 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0280242 | 0.731365 | 1 |
Onchocerca volvulus | Nischarin homolog | 0.0100246 | 0.167725 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.00992078 | 0.164474 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0181034 | 0.420705 | 0.474611 |
Entamoeba histolytica | type A flavoprotein, putative | 0.00992078 | 0.164474 | 0.5 |
Treponema pallidum | flavodoxin | 0.00992078 | 0.164474 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0280242 | 0.731365 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0257105 | 0.658914 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.00992078 | 0.164474 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0181034 | 0.420705 | 0.474611 |
Brugia malayi | FAD binding domain containing protein | 0.0280242 | 0.731365 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0181034 | 0.420705 | 0.474611 |
Brugia malayi | FAD binding domain containing protein | 0.0181034 | 0.420705 | 0.575233 |
Loa Loa (eye worm) | hypothetical protein | 0.0280242 | 0.731365 | 1 |
Echinococcus granulosus | nischarin | 0.0103297 | 0.17728 | 0.0629291 |
Echinococcus multilocularis | methionine synthase reductase | 0.0181034 | 0.420705 | 0.474611 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0122345 | 0.236925 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0257105 | 0.658914 | 0.872195 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0280242 | 0.731365 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0280242 | 0.731365 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.00992078 | 0.164474 | 0.0412714 |
Loa Loa (eye worm) | hypothetical protein | 0.0100246 | 0.167725 | 0.0467702 |
Giardia lamblia | Hypothetical protein | 0.0257105 | 0.658914 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0122345 | 0.236925 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Brugia malayi | flavodoxin family protein | 0.00992078 | 0.164474 | 0.224886 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0122345 | 0.236925 | 0.163802 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0280242 | 0.731365 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0181034 | 0.420705 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0280242 | 0.731365 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0157897 | 0.348254 | 0.35208 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0366029 | 1 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.00914146 | 0.14007 | 0.191519 |
Entamoeba histolytica | type A flavoprotein, putative | 0.00992078 | 0.164474 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0280242 | 0.731365 | 1 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.016782 | 0.379325 | 0.404629 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0280242 | 0.731365 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0340252 | 0.919283 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.7 uM | Cytotoxicity against human MRC5 cells | ChEMBL. | 25089179 |
IC50 (binding) | = 2 uM | Inhibition of dopamine beta-oxygenase (unknown origin) | ChEMBL. | 25089179 |
IC50 (functional) | = 2.2 uM | Cytotoxicity against mouse B16 cells | ChEMBL. | 25089179 |
IC50 (functional) | = 8.7 uM | Antimalarial activity against Plasmodium falciparum FCR-3/Gambia | ChEMBL. | 25089179 |
MIC (functional) | = 45 uM | Antibacterial activity against Escherichia coli NIHJ | ChEMBL. | 25089179 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25089179 | |
Mus musculus | ChEMBL23 | 25089179 | |
Plasmodium falciparum | ChEMBL23 | 25089179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.