Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Hyaluronidase | 0.0898 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.4082 | 0.4082 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0898 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0898 | 1 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0898 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0309 | 0.0309 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0898 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.081 | 0.8984 | 0.8952 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0309 | 0.0309 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.