Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0233 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3591 | 0.382 |
Brugia malayi | intermediate filament protein | 0.0011 | 0.0248 | 1 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0039 | 0.2436 | 0.2436 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0011 | 0.0248 | 0.0264 |
Echinococcus granulosus | lamin | 0.0011 | 0.0248 | 0.0264 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0102 | 0.7328 | 0.7794 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0011 | 0.0248 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0011 | 0.0248 | 0.0264 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | lamin | 0.0011 | 0.0248 | 0.0264 |
Echinococcus granulosus | geminin | 0.0067 | 0.4581 | 0.4872 |
Echinococcus granulosus | lamin dm0 | 0.0011 | 0.0248 | 0.0264 |
Echinococcus multilocularis | lamin | 0.0011 | 0.0248 | 0.0264 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0011 | 0.0248 | 0.0264 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0129 | 0.9402 | 1 |
Echinococcus multilocularis | musashi | 0.0011 | 0.0248 | 0.0264 |
Toxoplasma gondii | exonuclease III APE | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0011 | 0.0248 | 0.0264 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0248 | 0.5 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0007 | 0 | 0.5 |
Giardia lamblia | DNA repair protein RAD52 | 0.0136 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0011 | 0.0248 | 0.0264 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.4581 | 0.4872 |
Onchocerca volvulus | 0.0011 | 0.0248 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0248 | 0.0264 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0007 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0129 | 0.9402 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0007 | 0 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1098 | 0.1167 |
Echinococcus multilocularis | lamin dm0 | 0.0011 | 0.0248 | 0.0264 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0067 | 0.4581 | 0.4872 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.2436 | 0.2436 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3164 | 0.3366 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0129 | 0.9402 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.4581 | 0.4872 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.9402 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.9402 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.