Detailed information for compound 562663

Basic information

Technical information
  • TDR Targets ID: 562663
  • Name: [(2R,3S,4R,5R)-5-(2-amino-6-$l^{1}-selanyl-pu rin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl] methyl dihydrogen phosphate
  • MW: 425.173 | Formula: C10H13N5O7PSe
  • H donors: 5 H acceptors: 8 LogP: -3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc(N)nc2[Se])COP(=O)(O)O
  • InChi: 1S/C10H13N5O7PSe/c11-10-13-7-4(8(24)14-10)12-2-15(7)9-6(17)5(16)3(22-9)1-21-23(18,19)20/h2-3,5-6,9,16-17H,1H2,(H2,11,13,14)(H2,18,19,20)/t3-,5-,6-,9-/m1/s1
  • InChiKey: AYEWEWIVGMQEJG-UUOKFMHZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,3S,4R,5R)-5-(2-amino-6-$l^{1}-selanyl-9-purinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-azanyl-6-$l^{1}-selanyl-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate
  • [(2R,3S,4R,5R)-5-(2-amino-6-$l^{1}-selanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
  • 6-selenoguanosine 5'-phosphate
  • 39669-47-1
  • 6-Seleno-5'-guanylic acid
  • SeGMp

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0036 0.1766 0.1649
Schistosoma mansoni tar DNA-binding protein 0.0127 0.8435 1
Loa Loa (eye worm) TAR-binding protein 0.0127 0.8435 0.8435
Schistosoma mansoni hypothetical protein 0.0036 0.1766 0.1639
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0794 0.5
Schistosoma mansoni intermediate filament proteins 0.0027 0.1056 0.0748
Entamoeba histolytica hypothetical protein 0.0023 0.0794 0.2558
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.8435 0.8435
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.1766 0.1737
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0459 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0459 0.5
Schistosoma mansoni tar DNA-binding protein 0.0127 0.8435 1
Echinococcus multilocularis muscleblind protein 1 0.0149 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.1766 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.1766 0.1639
Echinococcus granulosus muscleblind protein 0.0149 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.1056 0.1056
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0794 1
Echinococcus granulosus lamin dm0 0.0027 0.1056 0.1023
Echinococcus multilocularis lamin 0.0027 0.1056 0.1023
Echinococcus granulosus tar DNA binding protein 0.0127 0.8435 0.8429
Echinococcus granulosus lamin 0.0027 0.1056 0.1023
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.102 0.102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0459 0.0425
Entamoeba histolytica hypothetical protein 0.0036 0.1766 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1056 0.1056
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0794 0.5
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0794 1
Loa Loa (eye worm) RNA binding protein 0.0127 0.8435 0.8435
Echinococcus multilocularis muscleblind protein 0.0149 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.516 0.516
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0794 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.1056 0.1056
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0459 0.0459
Brugia malayi RNA binding protein 0.0127 0.8435 0.8413
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0794 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0794 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0459 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.1766 0.1737
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.8435 0.8413
Brugia malayi intermediate filament protein 0.0027 0.1056 0.0928
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0459 0.0323
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0794 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0459 0.5
Echinococcus multilocularis musashi 0.0027 0.1056 0.1023
Echinococcus multilocularis lamin dm0 0.0027 0.1056 0.1023
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.516 0.5894
Brugia malayi TAR-binding protein 0.0127 0.8435 0.8413
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.516 0.5143
Entamoeba histolytica hypothetical protein 0.0036 0.1766 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0794 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0459 0.0425
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0794 1
Schistosoma mansoni lamin 0.0027 0.1056 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0127 0.8435 1
Echinococcus granulosus intermediate filament protein 0.0027 0.1056 0.1023
Echinococcus multilocularis tar DNA binding protein 0.0127 0.8435 0.8429
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.1056 0.0928
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.516 0.5143
Onchocerca volvulus 0.0083 0.516 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0794 1
Entamoeba histolytica hypothetical protein 0.0036 0.1766 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.516 0.5091
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0459 0.5
Schistosoma mansoni tar DNA-binding protein 0.0127 0.8435 1
Schistosoma mansoni lamin 0.0027 0.1056 0.0748
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0141 0.0141
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0794 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.8435 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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