Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0038 | 0.1768 | 0.1651 |
Mycobacterium leprae | conserved hypothetical protein | 0.0024 | 0.0794 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1768 | 0.164 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.8438 | 0.8438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.8438 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1768 | 0.1738 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.8438 | 0.8438 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.1056 | 0.0747 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0794 | 0.2555 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0459 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0459 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 1 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0024 | 0.0794 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.1056 | 0.1056 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1768 | 0.164 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1768 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.8438 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.1056 | 0.1023 |
Echinococcus multilocularis | lamin | 0.0028 | 0.1056 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.102 | 0.102 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0024 | 0.0794 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.1056 | 0.1023 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.8438 | 0.8432 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1056 | 0.1056 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0459 | 0.0425 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1768 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.0794 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.1056 | 0.1056 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.516 | 0.516 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 1 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0024 | 0.0794 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.8438 | 0.8438 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0024 | 0.0794 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0459 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0024 | 0.0794 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0024 | 0.0794 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0459 | 0.0459 |
Brugia malayi | RNA binding protein | 0.0131 | 0.8438 | 0.8415 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0459 | 0.0323 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.1056 | 0.0928 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1768 | 0.1738 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.8438 | 0.8415 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.1056 | 0.1023 |
Echinococcus multilocularis | musashi | 0.0028 | 0.1056 | 0.1023 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0459 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0024 | 0.0794 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0024 | 0.0794 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0459 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 1 | 1 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0085 | 0.516 | 0.5143 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1768 | 1 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.8438 | 0.8415 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0085 | 0.516 | 0.5892 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.1056 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.0036 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.1056 | 0.1023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.8438 | 0.8432 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0024 | 0.0794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.8438 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.1056 | 0.0747 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0085 | 0.516 | 0.5091 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1768 | 1 |
Onchocerca volvulus | 0.0085 | 0.516 | 1 | |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0024 | 0.0794 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0085 | 0.516 | 0.5143 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0024 | 0.0794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.8438 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.8438 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.1056 | 0.0747 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0141 | 0.0141 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0459 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.