Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.525 | 0.5082 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.525 | 0.5082 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0343 | 0.0674 |
Echinococcus multilocularis | jun protein | 0.0101 | 0.525 | 0.5082 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0343 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.1186 | 0.2334 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0748 | 0.042 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2069 | 0.1788 |
Onchocerca volvulus | 0.008 | 0.3938 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0718 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5083 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2069 | 0.1788 |
Schistosoma mansoni | lamin | 0.0027 | 0.0748 | 0.042 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0748 | 0.1471 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.2069 | 0.1788 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.1186 | 1 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.4105 | 0.3896 |
Schistosoma mansoni | lamin | 0.0027 | 0.0748 | 0.042 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0748 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0748 | 0.1471 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.525 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2069 | 0.1788 |
Echinococcus granulosus | lamin | 0.0027 | 0.0748 | 0.042 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0748 | 0.042 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.2069 | 0.3941 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.1186 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0748 | 0.1471 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.1186 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.1186 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0343 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.1186 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0748 | 0.042 |
Echinococcus multilocularis | geminin | 0.018 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0343 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0343 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0748 | 0.1424 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.1186 | 0.2259 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0748 | 0.042 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2069 | 0.1788 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0343 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.2069 | 0.4071 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4105 | 0.3896 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.1186 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0748 | 0.1424 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0343 | 0.0653 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.2069 | 0.1788 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.1186 | 0.0873 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.1186 | 1 |
Echinococcus granulosus | jun protein | 0.0101 | 0.525 | 0.5082 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.1186 | 0.0873 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.2069 | 0.1788 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0343 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0343 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0343 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0748 | 0.042 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.1186 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.3938 | 0.75 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.1186 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.