Detailed information for compound 564077

Basic information

Technical information
  • TDR Targets ID: 564077
  • Name: 2-(chloromethyl)pyridine
  • MW: 127.572 | Formula: C6H6ClN
  • H donors: 0 H acceptors: 1 LogP: 1.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCc1ccccn1
  • InChi: 1S/C6H6ClN/c7-5-6-3-1-2-4-8-6/h1-4H,5H2
  • InChiKey: NJWIMFZLESWFIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloromethylpyridine
  • NCGC00091692-02
  • C233
  • 2-CMP
  • 2-Picolyl chloride
  • Pyridine, 2-(chloromethyl)-
  • BB_SC-2985

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2069 0.1788
Brugia malayi bZIP transcription factor family protein 0.0101 0.525 1
Schistosoma mansoni hypothetical protein 0.018 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0718 0.1413
Echinococcus granulosus intermediate filament protein 0.0027 0.0748 0.042
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.1186 1
Schistosoma mansoni jun-related protein 0.0082 0.4105 0.3896
Echinococcus granulosus lamin 0.0027 0.0748 0.042
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0343 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0343 0.0674
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0343 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0343 0.5
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.1186 0.2334
Onchocerca volvulus 0.008 0.3938 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0343 0.0653
Echinococcus multilocularis lamin dm0 0.0027 0.0748 0.042
Echinococcus multilocularis lamin 0.0027 0.0748 0.042
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.1186 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0748 0.1471
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.1186 0.0873
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2069 0.1788
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.525 0.5082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2069 0.1788
Echinococcus multilocularis geminin 0.018 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.2069 0.1788
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.2069 0.4071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0748 0.1471
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.2069 0.3941
Loa Loa (eye worm) hypothetical protein 0.0099 0.5083 1
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.1186 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2069 0.1788
Schistosoma mansoni hypothetical protein 0.018 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0343 0.5
Brugia malayi Augmenter of liver regeneration 0.0034 0.1186 0.2259
Schistosoma mansoni lamin 0.0027 0.0748 0.042
Leishmania major hypothetical protein, conserved 0.0034 0.1186 1
Brugia malayi hypothetical protein 0.008 0.3938 0.75
Schistosoma mansoni intermediate filament proteins 0.0027 0.0748 0.042
Echinococcus granulosus jun protein 0.0101 0.525 0.5082
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.1186 0.0873
Schistosoma mansoni lamin 0.0027 0.0748 0.042
Schistosoma mansoni hypothetical protein 0.0082 0.4105 0.3896
Brugia malayi intermediate filament protein 0.0027 0.0748 0.1424
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.1186 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0748 0.1424
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0343 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0343 0.5
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.1186 1
Echinococcus granulosus lamin dm0 0.0027 0.0748 0.042
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.1186 1
Echinococcus multilocularis jun protein 0.0101 0.525 0.5082
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.1186 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0343 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0748 0.1471
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.1186 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0343 0.5
Echinococcus multilocularis musashi 0.0027 0.0748 0.042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.525 0.5082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.2069 0.1788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.2069 0.1788

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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