Detailed information for compound 564783

Basic information

Technical information
  • TDR Targets ID: 564783
  • Name: 2-methylguanidine
  • MW: 73.0971 | Formula: C2H7N3
  • H donors: 2 H acceptors: 0 LogP: -1.25 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN=C(N)N
  • InChi: 1S/C2H7N3/c1-5-2(3)4/h1H3,(H4,3,4,5)
  • InChiKey: CHJJGSNFBQVOTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Methylguanidine
  • 471-29-4
  • Methylguanidin [German]
  • Monomethyl guanidin [German]
  • Monomethylguanidine
  • N-Methylguanidine
  • MGX
  • CHEBI:16628
  • 1-methylguanidine
  • C02294
  • EINECS 207-438-3
  • Guanidine, methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.443 1
Schistosoma mansoni hypothetical protein 0.0034 0.1767 0.3414
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.2892 0.2892
Leishmania major aldo-keto reductase-like protein 0.0062 0.443 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.5175 1
Entamoeba histolytica aldose reductase, putative 0.0062 0.443 0.8502
Onchocerca volvulus 0.0062 0.443 1
Entamoeba histolytica hypothetical protein 0.007 0.5175 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.2892 0.2892
Echinococcus granulosus aldehyde reductase 0.0044 0.2706 0.5229
Schistosoma mansoni transcription factor LCR-F1 0.007 0.5175 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0062 0.443 1
Echinococcus multilocularis aldo keto reductase 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Entamoeba histolytica hypothetical protein 0.007 0.5175 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.443 1
Giardia lamblia Aldose reductase 0.0062 0.443 0.5
Schistosoma mansoni hypothetical protein 0.007 0.5175 1
Schistosoma mansoni aldo-keto reductase 0.0062 0.443 0.8561
Onchocerca volvulus 0.0062 0.443 1
Trypanosoma brucei aldo-keto reductase, putative 0.0062 0.443 1
Echinococcus granulosus hypothetical protein 0.0062 0.443 0.8561
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase 0.0062 0.443 0.8561
Echinococcus multilocularis aldo keto reductase 0.0062 0.443 0.8561
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.3289 0.3289
Giardia lamblia Aldose reductase 0.0062 0.443 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.1767 0.1767
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.3289 0.3289
Onchocerca volvulus 0.0062 0.443 1
Schistosoma mansoni pol-related 0.0062 0.443 0.8561
Loa Loa (eye worm) oxidoreductase 0.0062 0.443 0.443
Trypanosoma cruzi aldo/keto reductase, putative 0.0062 0.443 1
Loa Loa (eye worm) oxidoreductase 0.0062 0.443 0.443
Loa Loa (eye worm) oxidoreductase 0.0062 0.443 0.443
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.5175 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Leishmania major prostaglandin f synthase, putative 0.0062 0.443 1
Loa Loa (eye worm) hypothetical protein 0.005 0.3289 0.3289
Trypanosoma brucei prostaglandin f synthase 0.0062 0.443 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0018 0.0202 0.0202
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0062 0.443 1
Plasmodium vivax aldehyde reductase, putative 0.0018 0.0202 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2892 0.5589
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Echinococcus multilocularis aldehyde reductase 0.0044 0.2706 0.5229
Echinococcus multilocularis aldo keto reductase 0.0062 0.443 0.8561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2892 0.5589
Brugia malayi hypothetical protein 0.007 0.5175 0.5175
Plasmodium falciparum aldo-keto reductase, putative 0.0018 0.0202 0.5
Schistosoma mansoni aldo-keto reductase 0.0062 0.443 0.8561
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.443 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 1 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0018 0.0202 0.039
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Brugia malayi NADH-dependent xylose reductase 0.0018 0.0202 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2892 0.5589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2892 0.5589
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2892 0.5589
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.443 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0018 0.0202 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2892 0.5589
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0018 0.0202 0.0202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2892 0.5589
Onchocerca volvulus 0.0062 0.443 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.3289 0.3289
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Loa Loa (eye worm) oxidoreductase 0.0062 0.443 0.443
Echinococcus multilocularis aldo keto reductase 0.0062 0.443 0.8561
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.443 0.443
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0062 0.443 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0018 0.0202 0.5
Onchocerca volvulus 0.0062 0.443 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0018 0.0202 0.039
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.443 0.443
Echinococcus granulosus aldo keto reductase 0.0062 0.443 0.8561
Entamoeba histolytica aldose reductase, putative 0.0062 0.443 0.8502
Loa Loa (eye worm) hypothetical protein 0.0034 0.1767 0.1767
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0018 0.0202 0.039
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase 0.0062 0.443 0.8561
Schistosoma mansoni potassium channel beta 0.0018 0.0202 0.039
Loa Loa (eye worm) oxidoreductase 0.0062 0.443 0.443
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.443 0.8561
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.443 0.443
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.443 0.443
Onchocerca volvulus 0.0062 0.443 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0062 0.443 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.443 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.443 0.8561
Entamoeba histolytica aldose reductase, putative 0.0062 0.443 0.8502
Trypanosoma cruzi aldo-keto reductase 0.0062 0.443 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.443 0.443
Toxoplasma gondii aldose reductase, putative 0.0062 0.443 1
Entamoeba histolytica hypothetical protein 0.007 0.5175 1
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.2706 0.5922
Mycobacterium ulcerans oxidoreductase 0.0062 0.443 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.443 1
Entamoeba histolytica hypothetical protein 0.007 0.5175 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.443 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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