Detailed information for compound 564929

Basic information

Technical information
  • TDR Targets ID: 564929
  • Name: sanguinarine
  • MW: 397.358 | Formula: C20H17N2O7+
  • H donors: 2 H acceptors: 3 LogP: 1.44 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cc2c3OCOc3ccc2c2c1=C1C=C3OCOC3=CC1C=C2.O[N+](=O)O
  • InChi: 1S/C20H15NO4.H2NO3/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;2-1(3)4/h2-8,11H,9-10H2,1H3;(H2,2,3,4)/q;+1
  • InChiKey: VSJBSQHXURXHMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Sanguinarine, nitrate
  • [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-, nitrate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0145 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0311 0.0498
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.5866 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1905 0.4618
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0311 0.053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0145 0.0247
Plasmodium vivax glutathione reductase, putative 0.0038 0 0.5
Echinococcus granulosus ng dimethylarginine dimethylaminohydrolase 0.0185 0.5806 0.9897
Schistosoma mansoni lipoxygenase 0.0117 0.3149 0.5382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0311 0.0498
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0311 0.053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0185 0.5806 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1905 0.4618
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0569 0.0971
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0051 0.0087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.4125 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.5866 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.5806 0.9898
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0311 0.0498
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0763 0.1301
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1905 0.4618
Schistosoma mansoni alpha glucosidase 0.0041 0.0145 0.0163
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1905 0.4618
Schistosoma mansoni alpha-glucosidase 0.016 0.4842 0.8325
Leishmania major hypothetical protein, unknown function 0.0185 0.5806 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0145 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.5866 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 1 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0763 0.1301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0311 0.0451
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.5866 1
Plasmodium vivax thioredoxin reductase, putative 0.0038 0 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0145 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0311 0.0451
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0145 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.2283 0.5535
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.2283 0.5535
Plasmodium falciparum thioredoxin reductase 0.0038 0 0.5
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.4125 1
Brugia malayi Cytochrome P450 family protein 0.0052 0.0569 0.0971
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0145 1
Onchocerca volvulus 0.0185 0.5806 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.5866 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.2283 0.1705
Mycobacterium tuberculosis Probable reductase 0.0086 0.1905 0.4618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Schistosoma mansoni lipoxygenase 0.0082 0.1754 0.2958
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0145 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0311 0.0451
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.2283 0.5535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.4125 0.5
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.3149 0.5352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Plasmodium falciparum glutathione reductase 0.0038 0 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0311 0.0498
Brugia malayi NG,NG-dimethylarginine dimethylaminohydrolase 1, putative 0.0185 0.5806 0.9898
Treponema pallidum fructose-bisphosphate aldolase 0.0291 1 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0763 0.1301
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1905 0.4618
Leishmania major hypothetical protein, unknown function 0.0185 0.5806 1
Schistosoma mansoni ngng-dimethylarginine dimethylaminohydrolase 0.0185 0.5806 1
Trypanosoma brucei glucosidase, putative 0.0041 0.0145 1
Schistosoma mansoni alpha-glucosidase 0.016 0.4842 0.8325
Echinococcus multilocularis ng dimethylarginine dimethylaminohydrolase 0.0185 0.5806 0.9897
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0087
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0145 0.0249
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.3149 0.5352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0763 0.1301

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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