Detailed information for compound 566860

Basic information

Technical information
  • TDR Targets ID: 566860
  • Name: 1-iodopyrrolidine-2,5-dione
  • MW: 224.985 | Formula: C4H4INO2
  • H donors: 0 H acceptors: 2 LogP: -0.18 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: IN1C(=O)CCC1=O
  • InChi: 1S/C4H4INO2/c5-6-3(7)1-2-4(6)8/h1-2H2
  • InChiKey: LQZMLBORDGWNPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-iodopyrrolidine-2,5-quinone
  • N-iodosuccinimide
  • 516-12-1
  • EINECS 208-221-6
  • Succinimide, N-iodo-
  • Succiniodimide
  • 220051_ALDRICH
  • ZINC02141015
  • 58070_FLUKA
  • 2,5-Pyrrolidinedione, 1-iodo- (9CI)
  • 5-21-09-00544 (Beilstein Handbook Reference)
  • BRN 0113917

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TAR-binding protein 0.0062 0.4884 0.4884
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.1501 0.1501
Schistosoma mansoni hypothetical protein 0.0016 0.0541 0.1108
Onchocerca volvulus Peroxidase homolog 0.0026 0.1501 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.1501 0.1501
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.3652 0.3652
Brugia malayi Blistered cuticle protein 3 0.0026 0.1501 0.1501
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Brugia malayi hypothetical protein 0.0026 0.1501 0.1501
Chlamydia trachomatis DNA ligase 0.001 0 0.5
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0 0.5
Onchocerca volvulus Dual oxidase homolog 0.0026 0.1501 1
Onchocerca volvulus Peroxidasin homolog 0.0026 0.1501 1
Brugia malayi TAR-binding protein 0.0062 0.4884 0.4884
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0541 0.0541
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 1 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.4884 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0541 0.1108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0541 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4884 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.1501 0.1501
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0 0.5
Brugia malayi Peroxidasin 0.0026 0.1501 0.1501
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.1501 0.1501
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4884 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.3652 0.3652
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.1501 0.1501
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0 0.5
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0 0.5
Schistosoma mansoni peroxidasin 0.0026 0.1501 0.3074
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.4884 0.4884
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Schistosoma mansoni hypothetical protein 0.0016 0.0541 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4884 1
Schistosoma mansoni hypothetical protein 0.0016 0.0541 0.1108
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.2212 0.2212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0541 0.1108
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0 0.5
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0 0.5
Echinococcus multilocularis peroxidasin 0.0026 0.1501 0.3074
Echinococcus granulosus peroxidasin 0.0026 0.1501 0.3074
Toxoplasma gondii ATPase, AAA family protein 0.001 0 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.2212 0.4529
Brugia malayi Animal haem peroxidase family protein 0.0026 0.1501 0.1501
Entamoeba histolytica hypothetical protein 0.001 0 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0541 0.0541
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.3652 0.3652
Brugia malayi Animal haem peroxidase family protein 0.0026 0.1501 0.1501
Loa Loa (eye worm) RNA binding protein 0.0062 0.4884 0.4884
Schistosoma mansoni peroxidasin 0.0026 0.1501 0.3074
Trichomonas vaginalis conserved hypothetical protein 0.001 0 0.5
Onchocerca volvulus 0.0026 0.1501 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0541 0.1108
Onchocerca volvulus Peroxidasin homolog 0.0026 0.1501 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Brugia malayi RNA binding protein 0.0062 0.4884 0.4884
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4884 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.3652 0.3652
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.1501 0.1501
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0541 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.001 0 0.5
Onchocerca volvulus Peroxidase homolog 0.0026 0.1501 1
Echinococcus granulosus GPCR family 2 0.0016 0.0541 0.1108
Onchocerca volvulus 0.0026 0.1501 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4884 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Plasmodium vivax replication factor C subunit 1, putative 0.001 0 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0541 0.0541
Trypanosoma cruzi hypothetical protein, conserved 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Treponema pallidum DNA ligase (lig) 0.001 0 0.5
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0 0.5
Onchocerca volvulus 0.0026 0.1501 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.4884 0.4884
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0541 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0541 0.1108
Loa Loa (eye worm) hypothetical protein 0.0026 0.1501 0.1501
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.2212 0.2212
Loa Loa (eye worm) transcription factor SMAD2 0.0117 1 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.1501 0.1501
Giardia lamblia Replication factor C, subunit 1 0.001 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0062 0.4884 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.1501 0.1501

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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