Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Homo sapiens | phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | NNMT/PNMT/TEMT family protein | Phenylethanolamine N-methyltransferase | 283 aa | 254 aa | 26.0 % |
Brugia malayi | NNMT/PNMT/TEMT family protein | phenylethanolamine N-methyltransferase | 282 aa | 257 aa | 26.5 % |
Onchocerca volvulus | Putative Werner syndrome ATP-dependent helicase homolog 1 | Phenylethanolamine N-methyltransferase | 283 aa | 254 aa | 27.2 % |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | Phenylethanolamine N-methyltransferase | 283 aa | 245 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0716 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0321 | 0.1045 | 0.1045 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0453 | 0.4028 | 0.4028 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1175 | 0.0073 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0389 | 0.2581 | 0.4313 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0327 | 0.1175 | 0.1175 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0716 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1175 | 0.0073 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0667 | 0.888 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Schistosoma mansoni | glutamate receptor kainate | 0.0474 | 0.451 | 1 |
Echinococcus granulosus | glutamate receptor 4 | 0.0327 | 0.1175 | 0.1175 |
Echinococcus granulosus | glutamate receptor 1 | 0.0327 | 0.1175 | 0.1175 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Echinococcus multilocularis | glutamate receptor 2 | 0.059 | 0.7147 | 0.7147 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0652 | 0.8537 | 0.9559 |
Echinococcus granulosus | glutamate receptor 2 | 0.059 | 0.7147 | 0.7147 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1175 | 0.0073 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0325 | 0.1118 | 0.1118 |
Schistosoma mansoni | glutamate receptor kainate | 0.0474 | 0.451 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0538 | 0.5972 | 0.5972 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.888 | 1 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0667 | 0.888 | 1 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0453 | 0.4028 | 0.4028 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0716 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0652 | 0.8537 | 0.8537 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0325 | 0.1118 | 0.1118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = -0.82 | Calculated partition coefficient (clogP) | ChEMBL. | 10479290 |
Ki (binding) | = 0.64 uM | Affinity for bovine Phenylethanolamine N-Methyltransferase | ChEMBL. | 10479290 |
Ki (binding) | = 0.64 uM | Inhibition of bovine adrenal Phenylethanolamine N-Methyltransferase | ChEMBL. | 10354406 |
Ki (binding) | = 0.64 uM | Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro | ChEMBL. | 10464018 |
Ki (binding) | = 0.64 uM | Inhibitory constant against bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ki (binding) | = 0.64 uM | Affinity for bovine Phenylethanolamine N-Methyltransferase | ChEMBL. | 10479290 |
Ki (binding) | = 0.64 uM | Inhibition of bovine adrenal Phenylethanolamine N-Methyltransferase | ChEMBL. | 10354406 |
Ki (binding) | = 0.64 uM | Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro | ChEMBL. | 10464018 |
Ki (binding) | = 0.64 uM | Inhibitory constant against bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ki (binding) | = 2 uM | Inhibitory constant against human phenylethanolamine N-methyltransferase overexpressed in E. coli | ChEMBL. | 11412985 |
Ki (binding) | = 2 uM | Inhibitory constant against human phenylethanolamine N-methyltransferase overexpressed in E. coli | ChEMBL. | 11412985 |
Ki (binding) | = 660 uM | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | ChEMBL. | 10479290 |
Ki (binding) | = 660 uM | Displacement of [3H]-Clonidine from Alpha-2 adrenergic receptor of rat cortical membranes | ChEMBL. | 10354406 |
Ki (binding) | = 660 uM | Compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]-clonidine | ChEMBL. | 10464018 |
Ki (binding) | = 660 uM | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | ChEMBL. | 10479290 |
Ki (binding) | = 660 uM | Displacement of [3H]-Clonidine from Alpha-2 adrenergic receptor of rat cortical membranes | ChEMBL. | 10354406 |
Ki (binding) | = 660 uM | Compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]-clonidine | ChEMBL. | 10464018 |
Papp (functional) | = 72100 cm min-1 | Apparent permeability value of the compound through blood-brain barrier was evaluated using bovine brain microvessel endothelial cells (BBMEC) | ChEMBL. | 10479290 |
Ratio (binding) | = 1000 | Ratio for binding affinity towards alpha2 adenoceptor to PNMT | ChEMBL. | 10479290 |
Ratio (binding) | = 3.1 | Ki ratio of human versus bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ratio (binding) | = 1000 | Ratio for binding affinity towards alpha2 adenoceptor to PNMT | ChEMBL. | 10479290 |
Selectivity (binding) | = 1000 | Relative affinity for PNMT and alpha2 adrenergic receptors | ChEMBL. | 10354406 |
Selectivity (binding) | = 1000 | Selectivity determined by Ki of alpha 2 receptor / Ki of PNMT | ChEMBL. | 10464018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.