Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0164 | 0.5539 | 0.5485 |
Brugia malayi | acyl-CoA desaturase | 0.0164 | 0.5539 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0179 | 0.6196 | 0.615 |
Onchocerca volvulus | 0.0179 | 0.6196 | 0.5 | |
Leishmania major | stearic acid desaturase, putative | 0.0179 | 0.6196 | 0.3944 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0164 | 0.5539 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0179 | 0.6196 | 0.3944 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0262 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.4357 | 0.5 |
Echinococcus granulosus | geminin | 0.0193 | 0.685 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.685 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0262 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0138 | 0.4357 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0124 | 0.372 | 0.3643 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0262 | 1 | 1 |
Onchocerca volvulus | 0.0179 | 0.6196 | 0.5 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0179 | 0.6196 | 0.3944 |
Toxoplasma gondii | hypothetical protein | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0164 | 0.5539 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0164 | 0.5539 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0164 | 0.5539 | 0.5485 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.685 | 1 |
Echinococcus multilocularis | geminin | 0.0193 | 0.685 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.