TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 205.21 | Formula: C11H11NO3
H donors: 1 H acceptors: 2 LogP: 1.94 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@@]1(OC(=O)NC1=O)c1ccccc1
InChi: 1S/C11H11NO3/c1-2-11(8-6-4-3-5-7-8)9(13)12-10(14)15-11/h3-7H,2H2,1H3,(H,12,13,14)/t11-/m1/s1
InChiKey: SGQOVJBGRJMVJR-LLVKDONJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0094	0.1395	0.1924
Onchocerca volvulus		0.0094	0.1395	0.0664
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0171	0.3152	0.4561
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Echinococcus granulosus	neuropeptide Y receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0094	0.1395	0.4218
Brugia malayi	hypothetical protein	0.0079	0.1055	0.1413
Brugia malayi	Carboxylesterase family protein	0.0071	0.0873	0.114
Schistosoma mansoni	neurotransmitter gated ion channel	0.0079	0.1055	0.2915
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	carboxylesterase 5A	0.0071	0.0873	0.25
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0092	0.1356	0.1865
Onchocerca volvulus		0.0094	0.1395	0.0664
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0094	0.1395	0.4218
Echinococcus granulosus	dro:myosuppressin receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	dro:myosuppressin receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Echinococcus granulosus	nAChR subunit	0.0092	0.1356	0.409
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0171	0.3152	0.4561
Schistosoma mansoni	nAChR subunit	0.0079	0.1055	0.2915
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.1395	0.4218
Plasmodium falciparum	telomerase reverse transcriptase	0.0083	0.1149	0.5
Giardia lamblia	Telomerase catalytic subunit	0.0083	0.1149	0.5
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0079	0.1055	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0113	0.0113
Brugia malayi	Dopamine receptor protein 2	0.0094	0.1395	0.1924
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0092	0.1356	0.1865
Echinococcus multilocularis	neuropeptide receptor	0.0094	0.1395	0.4218
Brugia malayi	G-protein coupled receptor	0.0094	0.1395	0.1924
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0079	0.1055	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0171	0.3152	1
Echinococcus granulosus	orexin receptor type 2	0.0094	0.1395	0.4218
Echinococcus granulosus	g protein coupled receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0171	0.3152	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0094	0.1395	0.1395
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0171	0.3152	1
Brugia malayi	AKH receptor	0.0094	0.1395	0.1924
Onchocerca volvulus		0.0094	0.1395	0.0664
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0171	0.3152	1
Loa Loa (eye worm)	GABA receptor subunit	0.0092	0.1356	0.1356
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0171	0.3152	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Schistosoma mansoni	acetylcholine receptor-related	0.0079	0.1055	0.2915
Loa Loa (eye worm)	neuropeptide F receptor	0.0094	0.1395	0.1395
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	somatostatin receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.0873	0.25
Echinococcus granulosus	G protein coupled receptor 139	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0094	0.1395	0.4218
Entamoeba histolytica	hypothetical protein	0.0092	0.1356	0.5
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0256	0.5102	1
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0083	0.1149	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0057	0.5
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.1395	0.4065
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0092	0.1356	0.3934
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Brugia malayi	G-protein coupled receptor	0.0094	0.1395	0.1924
Brugia malayi	Serotonin receptor	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Schistosoma mansoni	biogenic amine receptor	0.0094	0.1395	0.4065
Onchocerca volvulus		0.0094	0.1395	0.0664
Schistosoma mansoni	growth hormone secretagogue receptor	0.0094	0.1395	0.4065
Brugia malayi	larval opioid receptor	0.0094	0.1395	0.1924
Schistosoma mansoni	neurotransmitter gated ion channel	0.0079	0.1055	0.2915
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0171	0.3152	1
Echinococcus granulosus	g protein coupled receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	neuropeptide F-like receptor	0.0094	0.1395	0.4065
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0083	0.1149	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0079	0.1055	0.2915
Onchocerca volvulus		0.0171	0.3152	0.4092
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Onchocerca volvulus		0.0094	0.1395	0.0664
Brugia malayi	hypothetical protein	0.0079	0.1055	0.1413
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0094	0.1395	0.4218
Brugia malayi	ORL1-like opioid receptor	0.0094	0.1395	0.1924
Echinococcus granulosus	carboxylesterase 5A	0.0071	0.0873	0.25
Brugia malayi	Cation transporter family protein	0.0171	0.3152	0.4561
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Echinococcus multilocularis	sex peptide receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Schistosoma mansoni	nAChR subunit	0.0079	0.1055	0.2915
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Schistosoma mansoni	hypothetical protein	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Echinococcus granulosus	neuropeptide receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0079	0.1055	0.3098
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0171	0.3152	1
Echinococcus granulosus	g-protein coupled receptor	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0171	0.3152	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0094	0.1395	0.1395
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Echinococcus granulosus	7TM GPCR rhodopsin	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Schistosoma mansoni	neuropeptide receptor	0.0094	0.1395	0.4065
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Echinococcus multilocularis	neuropeptide s receptor	0.0094	0.1395	0.4218
Onchocerca volvulus	Putative nachr subunit	0.0171	0.3152	0.4092
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0873	0.0873
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Brugia malayi	excitatory GABA receptor EXP-1A	0.0171	0.3152	0.4561
Echinococcus granulosus	fmrfamide receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	neuropeptide receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	neuropeptide receptor A26	0.0094	0.1395	0.4218
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0092	0.1356	0.3934
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0094	0.1395	0.4218
Echinococcus granulosus	neuropeptide receptor A26	0.0094	0.1395	0.4218
Leishmania major	telomerase reverse transcriptase, putative	0.0083	0.1149	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Onchocerca volvulus		0.0094	0.1395	0.0664
Echinococcus granulosus	allatostatin A receptor	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Echinococcus granulosus	neuropeptide Y receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Onchocerca volvulus		0.0094	0.1395	0.0664
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0079	0.1055	0.1413
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Echinococcus granulosus	serotonin receptor	0.0094	0.1395	0.4218
Brugia malayi	Dopamine receptor protein 1	0.0094	0.1395	0.1924
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0171	0.3152	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0171	0.3152	1
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.4981	0.4981
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0079	0.1055	0.1055
Echinococcus granulosus	neuropeptide FF receptor 2	0.0094	0.1395	0.4218
Schistosoma mansoni	neuropeptide receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0303	0.6182	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.0873	0.2301
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Schistosoma mansoni	myosin xvIII	0.0094	0.1395	0.4065
Brugia malayi	sulfakinin receptor protein	0.0094	0.1395	0.1924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	neuropeptide s receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0171	0.3152	0.3152
Echinococcus multilocularis	serotonin receptor	0.0094	0.1395	0.4218
Echinococcus granulosus	somatostatin receptor	0.0094	0.1395	0.4218
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0171	0.3152	1
Brugia malayi	Melatonin receptor type 1A	0.0094	0.1395	0.1924
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0873	0.0873
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Schistosoma mansoni	opsin-like receptor	0.0094	0.1395	0.4065
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Echinococcus granulosus	acetylcholinesterase	0.0071	0.0873	0.25
Brugia malayi	neuropeptide F receptor	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	biogenic amine 5HT receptor	0.0094	0.1395	0.4218
Echinococcus granulosus	neuropeptide receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	neuropeptide Y receptor	0.0094	0.1395	0.4218
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0171	0.3152	0.4561
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0094	0.1395	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0171	0.3152	1
Brugia malayi	G protein-coupled receptor	0.0094	0.1395	0.1924
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	neuropeptide Y receptor	0.0094	0.1395	0.4218
Brugia malayi	Cation transporter family protein	0.0171	0.3152	0.4561
Loa Loa (eye worm)	carboxylesterase	0.0071	0.0873	0.0873
Schistosoma mansoni	neurotransmitter gated ion channel	0.0092	0.1356	0.3934
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Loa Loa (eye worm)	melatonin receptor type 1A	0.0094	0.1395	0.1395
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1055	0.1413
Onchocerca volvulus		0.0094	0.1395	0.0664
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Echinococcus granulosus	neuropeptides capa receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	glycine receptor subunit beta	0.0171	0.3152	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0094	0.1395	0.4065
Schistosoma mansoni	amine GPCR	0.0094	0.1395	0.4065
Onchocerca volvulus		0.0171	0.3152	0.4092
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0094	0.1395	0.1395
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0171	0.3152	0.4561
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0171	0.3152	0.3152
Echinococcus multilocularis	neuropeptides capa receptor	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Schistosoma mansoni	neuropeptide F-like receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	G protein coupled receptor 139	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	orexin receptor type 2	0.0094	0.1395	0.4218
Loa Loa (eye worm)	LGC-31 protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	acetylcholinesterase 1	0.0071	0.0873	0.0873
Echinococcus multilocularis	glycine receptor subunit beta	0.0171	0.3152	1
Echinococcus granulosus	glycine receptor subunit beta	0.0171	0.3152	1
Echinococcus multilocularis	serotonin receptor	0.0094	0.1395	0.4218
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Schistosoma mansoni	amine GPCR	0.0094	0.1395	0.4065
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0094	0.1395	0.1924
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0171	0.3152	0.4561
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	acetylcholine receptor protein	0.0079	0.1055	0.1055
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0171	0.3152	1
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.0873	0.25
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0094	0.1395	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Trypanosoma brucei	telomerase reverse transcriptase	0.0083	0.1149	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Schistosoma mansoni	amine GPCR	0.0094	0.1395	0.4065
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	opsin-like receptor	0.0094	0.1395	0.4065
Echinococcus granulosus	7tm_1 domain containing protein	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	g-protein coupled receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0171	0.3152	1
Schistosoma mansoni	biogenic amine receptor	0.0094	0.1395	0.4065
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0171	0.3152	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0094	0.1395	0.4218
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0094	0.1395	0.4218
Echinococcus granulosus	g protein coupled receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.1395	0.4218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	hypothetical protein	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Schistosoma mansoni	biogenic amine receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	neuropeptides capa receptor	0.0094	0.1395	0.4218
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0171	0.3152	1
Loa Loa (eye worm)	ACC-1 protein	0.0171	0.3152	0.3152
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0083	0.1149	0.5
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	RE15519p	0.0094	0.1395	0.1924
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0094	0.1395	0.1924
Schistosoma mansoni	neuropeptide receptor	0.0094	0.1395	0.4065
Echinococcus granulosus	biogenic amine 5HT receptor	0.0094	0.1395	0.4218
Onchocerca volvulus		0.0094	0.1395	0.0664
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1055	0.1413
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0171	0.3152	0.4561
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0094	0.1395	0.4065
Brugia malayi	Telomerase reverse transcriptase	0.0221	0.4291	0.6268
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0092	0.1356	0.1865
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0171	0.3152	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0094	0.1395	0.4218
Echinococcus granulosus	sex peptide receptor	0.0094	0.1395	0.4218
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0057	0.5
Echinococcus multilocularis	nAChR subunit	0.0171	0.3152	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0079	0.1055	0.3098
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	glycine receptor subunit beta	0.0171	0.3152	1
Onchocerca volvulus		0.0092	0.1356	0.0588
Echinococcus multilocularis	allatostatin A receptor	0.0094	0.1395	0.4218
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Brugia malayi	putative neuropeptide receptor	0.0094	0.1395	0.1924
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Onchocerca volvulus		0.0171	0.3152	0.4092
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0094	0.1395	0.1924
Echinococcus multilocularis	fmrfamide receptor	0.0094	0.1395	0.4218
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	follicle stimulating hormone receptor	0.0094	0.1395	0.1924
Onchocerca volvulus		0.0092	0.1356	0.0588
Schistosoma mansoni	hypothetical protein	0.0094	0.1395	0.4065
Onchocerca volvulus		0.0171	0.3152	0.4092
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0171	0.3152	1
Schistosoma mansoni	opsin-like receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	TYRA-2 protein	0.0094	0.1395	0.1395
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0171	0.3152	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0171	0.3152	1
Onchocerca volvulus		0.0171	0.3152	0.4092
Loa Loa (eye worm)	ACC-1 protein	0.0171	0.3152	0.3152
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0171	0.3152	0.4561
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0171	0.3152	0.3152
Brugia malayi	Dopamine receptor	0.0094	0.1395	0.1924
Loa Loa (eye worm)	neuropeptide F receptor	0.0094	0.1395	0.1395
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0094	0.1395	0.4218
Echinococcus multilocularis	nAChR subunit	0.0092	0.1356	0.409
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0094	0.1395	0.1395
Brugia malayi	hypothetical protein	0.0079	0.1055	0.1413
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0079	0.1055	0.1413
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0094	0.1395	0.4065
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0171	0.3152	0.4561
Schistosoma mansoni	amine GPCR	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Schistosoma mansoni	adenoreceptor	0.0094	0.1395	0.4065
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0171	0.3152	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Echinococcus granulosus	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Brugia malayi	GnHR receptor homolog	0.0094	0.1395	0.1924
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0094	0.1395	0.1924
Schistosoma mansoni	nAChR subunit	0.0171	0.3152	1
Echinococcus multilocularis	g protein coupled receptor	0.0094	0.1395	0.4218
Brugia malayi	putative neuropeptide receptor NPR1	0.0094	0.1395	0.1924
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0094	0.1395	0.1395
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Onchocerca volvulus		0.0094	0.1395	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0079	0.1055	0.3098
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1356	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus granulosus	nAChR subunit	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Brugia malayi	Serotonin receptor	0.0094	0.1395	0.1924
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0171	0.3152	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0094	0.1395	0.1395
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0171	0.3152	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Echinococcus multilocularis	fmrfamide receptor	0.0094	0.1395	0.4218
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0094	0.1395	0.4218
Brugia malayi	Cation transporter family protein	0.0171	0.3152	0.4561
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0094	0.1395	0.4065
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0092	0.1356	0.1865
Brugia malayi	hypothetical protein	0.0094	0.1395	0.1924
Brugia malayi	G protein-coupled receptor F59B2.13	0.0094	0.1395	0.1924
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0094	0.1395	0.4218
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0079	0.1055	0.1413
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0094	0.1395	0.4065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0094	0.1395	0.4065
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0079	0.1055	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1055	0.1055
Schistosoma mansoni	neuropeptide f receptor 76f	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0094	0.1395	0.1395
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0094	0.1395	0.4065
Onchocerca volvulus		0.0094	0.1395	0.0664
Schistosoma mansoni	hypothetical protein	0.0094	0.1395	0.4065
Schistosoma mansoni	neuropeptide receptor	0.0094	0.1395	0.4065
Loa Loa (eye worm)	hypothetical protein	0.033	0.6778	0.6778
Brugia malayi	hypothetical protein	0.0079	0.1055	0.1413
Echinococcus granulosus	neuropeptides capa receptor	0.0094	0.1395	0.4218
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0171	0.3152	0.4561
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.033	0.6778	1
Brugia malayi	neuropeptide F receptor	0.0094	0.1395	0.1924
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0094	0.1395	0.4218
Echinococcus granulosus	acetylcholinesterase	0.0071	0.0873	0.25
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0094	0.1395	0.4218
Schistosoma mansoni	hypothetical protein	0.0094	0.1395	0.4065
Schistosoma mansoni	histamine h1 receptor	0.0094	0.1395	0.4065
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0094	0.1395	0.4218
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0171	0.3152	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0094	0.1395	0.4218
Schistosoma mansoni	amine GPCR	0.0094	0.1395	0.4065
Brugia malayi	hypothetical protein	0.0079	0.1055	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3152	0.3152
Brugia malayi	Carboxylesterase family protein	0.0071	0.0873	0.114
Onchocerca volvulus		0.0171	0.3152	0.4092
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0171	0.3152	0.4561
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0079	0.1055	0.3098
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1395	0.1395

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 91 mg kg-1	Anticonvulsant activity of the compound, 0.5 h after administration in maximal electroshock mice model	ChEMBL.	2544727
ED50 (functional)	= 91 mg kg-1	Anticonvulsant activity of the compound, 0.5 h after administration in maximal electroshock mice model	ChEMBL.	2544727
ED50 (functional)	= 108 mg kg-1	Anticonvulsant activity of the compound, 0.5 h after administration of compound in mice subjected to subcutaneous metrazole challenge (85 mg/kg)	ChEMBL.	2544727
ED50 (functional)	= 108 mg kg-1	Anticonvulsant activity of the compound, 0.5 h after administration of compound in mice subjected to subcutaneous metrazole challenge (85 mg/kg)	ChEMBL.	2544727
Inhibition (binding)	= 46 %	Displacement of [3H]-BTX-B from rat cerebral cortex voltage-gated sodium channel, 0.5 hr after 500 uM	ChEMBL.	2544727
Inhibition (binding)	= 46 %	Displacement of [3H]-BTX-B from rat cerebral cortex voltage-gated sodium channel, 0.5 hr after 500 uM	ChEMBL.	2544727
TD50 (ADMET)	= 172 mg kg-1	Anticonvulsant activity of the compound,0.5 h after administration in mice subjected to rotorod toxicity test	ChEMBL.	2544727
TD50 (ADMET)	= 172 mg kg-1	Anticonvulsant activity of the compound,0.5 h after administration in mice subjected to rotorod toxicity test	ChEMBL.	2544727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL289443

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 56916