Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | choline:ethanolamine kinase | 0.0385 | 0.293 | 0.4401 |
Onchocerca volvulus | 0.0182 | 0.0856 | 0.1287 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | acetylcholinesterase | 0.0437 | 0.3462 | 0.5202 |
Plasmodium vivax | choline kinase, putative | 0.0385 | 0.293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0751 | 0.6656 | 0.6656 |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0291 | 0.1969 | 0.2958 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0291 | 0.1969 | 0.5686 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0182 | 0.0853 | 0.1282 |
Onchocerca volvulus | 0.0252 | 0.1577 | 0.2369 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0856 | 0.0856 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0182 | 0.0853 | 0.2465 |
Onchocerca volvulus | Putative nachr subunit | 0.0751 | 0.6656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0385 | 0.293 | 0.293 |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Brugia malayi | Cation transporter family protein | 0.0252 | 0.1577 | 0.1577 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0437 | 0.3462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0856 | 0.0856 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0182 | 0.0853 | 0.2465 |
Loa Loa (eye worm) | carboxylesterase | 0.0437 | 0.3462 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Schistosoma mansoni | hypothetical protein | 0.0328 | 0.2344 | 0.6771 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.1969 | 0.1969 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0182 | 0.0853 | 0.2465 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0856 | 0.0856 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0751 | 0.6656 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0182 | 0.0853 | 0.1282 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0259 | 0.1645 | 0.475 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0182 | 0.0853 | 0.1282 |
Echinococcus multilocularis | nAChR subunit | 0.0182 | 0.0853 | 0.1282 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0182 | 0.0853 | 0.1282 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0751 | 0.6656 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | serotonin receptor | 0.0291 | 0.1969 | 0.2958 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.2344 | 0.2344 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0182 | 0.0853 | 0.0853 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0328 | 0.2344 | 0.6771 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Cation transporter family protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Serotonin receptor | 0.0511 | 0.4212 | 0.4212 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0182 | 0.0853 | 0.1282 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0385 | 0.293 | 0.293 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0182 | 0.0853 | 0.0853 |
Onchocerca volvulus | 0.0252 | 0.1577 | 0.2369 | |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.3462 | 0.3462 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.0856 | 0.2474 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Carboxylesterase family protein | 0.0437 | 0.3462 | 0.3462 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0328 | 0.2344 | 0.3522 |
Onchocerca volvulus | 0.0182 | 0.0853 | 0.1282 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0751 | 0.6656 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0252 | 0.1577 | 0.4554 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0437 | 0.3462 | 0.5202 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0437 | 0.3462 | 0.3462 |
Onchocerca volvulus | 0.0182 | 0.0853 | 0.1282 | |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0182 | 0.0853 | 0.1282 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Dopamine receptor protein 1 | 0.0465 | 0.3742 | 0.3742 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.0856 | 0.0856 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0253 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.3742 | 0.3742 |
Loa Loa (eye worm) | hypothetical protein | 0.0751 | 0.6656 | 0.6656 |
Echinococcus multilocularis | serotonin receptor | 0.0291 | 0.1969 | 0.2958 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | LGC-31 protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0385 | 0.293 | 0.4401 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | ACC-1 protein | 0.0182 | 0.0853 | 0.0853 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.0856 | 0.0856 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.1969 | 0.1969 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Onchocerca volvulus | 0.0252 | 0.1577 | 0.2369 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0751 | 0.6656 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0751 | 0.6656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3462 | 0.3462 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.0856 | 0.2474 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0182 | 0.0853 | 0.0853 |
Plasmodium falciparum | choline kinase | 0.0385 | 0.293 | 0.5 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0182 | 0.0853 | 0.1282 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0182 | 0.0853 | 0.1282 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1577 | 0.1577 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1079 | 1 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0853 | 0.0853 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1079 | 1 | 0.5 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0182 | 0.0853 | 0.0853 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0182 | 0.0853 | 0.2465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0437 | 0.3462 | 0.5202 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.0856 | 0.1287 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0252 | 0.1577 | 0.4554 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.0856 | 0.0856 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0182 | 0.0853 | 0.1282 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0182 | 0.0853 | 0.0853 |
Loa Loa (eye worm) | ACC-1 protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0751 | 0.6656 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.4624 | 0.4624 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0385 | 0.293 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0182 | 0.0853 | 0.1282 |
Echinococcus granulosus | acetylcholinesterase | 0.0437 | 0.3462 | 0.5202 |
Echinococcus granulosus | carboxylesterase 5A | 0.0437 | 0.3462 | 0.5202 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0751 | 0.6656 | 0.6656 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0182 | 0.0853 | 0.0853 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0328 | 0.2344 | 0.3522 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1577 | 0.1577 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0182 | 0.0853 | 0.0853 |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Echinococcus granulosus | nAChR subunit | 0.0182 | 0.0853 | 0.1282 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.0856 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3462 | 0.3462 |
Echinococcus multilocularis | acetylcholinesterase | 0.0437 | 0.3462 | 0.5202 |
Onchocerca volvulus | 0.0182 | 0.0853 | 0.1282 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0182 | 0.0853 | 0.1282 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.0856 | 0.1287 |
Schistosoma mansoni | nAChR subunit | 0.0182 | 0.0853 | 0.2465 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1079 | 1 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.0856 | 0.0856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | Compound was tested for the neuroleptic activity as measured by it''s antagonism of d-amphetamine induced lethality in grouped mice(GAL) when administered perorally; Inactive at 20 mg/kg | ChEMBL. | 6110781 |
MDD50 (functional) | = 4.1 mg kg-1 | Reduction in motor activity in rats following p.o. administration. | ChEMBL. | 6110781 |
MED (functional) | = 1.56 mg kg-1 | Minimum effective dose of the compound causing antagonism of tetrabenazine induced depression in mice was determined when administered perorally | ChEMBL. | 6110781 |
MED (functional) | = 1.56 mg kg-1 | Minimum effective dose of the compound causing antagonism of tetrabenazine induced depression in mice was determined when administered perorally | ChEMBL. | 6110781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.