Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.3387 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3387 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0.3387 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.3387 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.3387 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3387 | 0.3387 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3387 | 0.3387 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3387 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.3387 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3387 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.