Detailed information for compound 572563

Basic information

Technical information
  • TDR Targets ID: 572563
  • Name: 3,8-dihydroxytetralin-1-one
  • MW: 178.185 | Formula: C10H10O3
  • H donors: 2 H acceptors: 3 LogP: 1.24 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CC(=O)c2c(C1)cccc2O
  • InChi: 1S/C10H10O3/c11-7-4-6-2-1-3-8(12)10(6)9(13)5-7/h1-3,7,11-12H,4-5H2
  • InChiKey: AQTKGZASUQVMEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,8-dihydroxy-1-tetralinone
  • 3,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one
  • vermelone
  • 59796-04-2
  • 1(2H)-Naphthalenone, 3,4-dihydro-3,8-dihydroxy-
  • 3,8-Dihydroxy-3,4-dihydronaphthalen-1(2H)-one
  • 3,8-Dihydroxy-3,4-dihydro-1(2H)-naphthalenone
  • 3,4-Dihydro-3,8-dihydroxy-1(2H)-naphthalenone
  • C01624

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0068 0.0146
Trichomonas vaginalis set domain proteins, putative 0.0251 0.5346 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0364 0.0783
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.3597 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0765 0.1643
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0456 1 0.5
Plasmodium vivax SET domain protein, putative 0.0032 0.0364 0.0298
Plasmodium vivax peptide deformylase, putative 0.0456 1 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0456 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0411 0.0883
Toxoplasma gondii hypothetical protein 0.0456 1 1
Brugia malayi Pre-SET motif family protein 0.022 0.4654 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4654 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0068 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0338 0.9275
Schistosoma mansoni hypothetical protein 0.0034 0.0411 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0411 0.0883
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0364 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.3597 1
Mycobacterium ulcerans peptide deformylase 0.0456 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.1657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0364 0.8867
Leishmania major polypeptide deformylase-like protein, putative 0.0174 0.3597 1
Treponema pallidum polypeptide deformylase (def) 0.0456 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0364 0.0298
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.3597 1
Onchocerca volvulus 0.0251 0.5346 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0364 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0364 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0765 0.1643
Brugia malayi Pre-SET motif family protein 0.0032 0.0364 0.0783
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.3597 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0765 0.1643
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0068 0.5
Plasmodium falciparum peptide deformylase 0.0456 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0765 0.1643
Trypanosoma brucei Peptide deformylase 2 0.0174 0.3597 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0068 0.1869
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0364 0.8867
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0068 0.1869
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0456 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.1657
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0068 0.0146
Trypanosoma brucei Polypeptide deformylase 1 0.0174 0.3597 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0364 0.8867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0364 0.8867

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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