Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.1164 | 0.2152 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0174 | 0.0166 | 0.2718 |
Schistosoma mansoni | kinesin eg-5 | 0.0174 | 0.0166 | 0.077 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0395 | 0.061 | 0.2834 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0395 | 0.061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0174 | 0.0166 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.5075 | 1 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0395 | 0.061 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0395 | 0.061 | 1 |
Brugia malayi | hypothetical protein | 0.0395 | 0.061 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0395 | 0.061 | 0.5 |
Brugia malayi | Kinesin motor domain containing protein | 0.0174 | 0.0166 | 0.2718 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0395 | 0.061 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.1337 | 0.2501 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0395 | 0.061 | 1 |
Echinococcus granulosus | kinesin family 1 | 0.1337 | 0.2501 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.468 | 0.9207 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0395 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0395 | 0.061 | 0.2834 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0395 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0395 | 0.061 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0395 | 0.061 | 1 |
Onchocerca volvulus | 0.0395 | 0.061 | 1 | |
Schistosoma mansoni | amine oxidase | 0.0395 | 0.061 | 0.2834 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0395 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.061 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0395 | 0.061 | 1 |
Giardia lamblia | Kinesin-5 | 0.0174 | 0.0166 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0395 | 0.061 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0395 | 0.061 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0395 | 0.061 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0395 | 0.061 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0395 | 0.061 | 0.2834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 10 ug ml-1 | Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560 | ChEMBL. | 2840501 |
IC50 (functional) | = 10 ug ml-1 | Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560 | ChEMBL. | 2840501 |
MIC (functional) | = 1.56 ug ml-1 | In vitro Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P | ChEMBL. | 2840501 |
MIC (functional) | = 3.1 ug ml-1 | In vitro Minimum inhibitory concentration against Escherichia coli Juhl | ChEMBL. | 2840501 |
MIC (functional) | = 3.1 ug ml-1 | In vitro Minimum inhibitory concentration against Klebsiella pneumoniae 8045 | ChEMBL. | 2840501 |
MIC (functional) | = 3.1 ug ml-1 | In vitro Minimum inhibitory concentration against Escherichia coli Juhl | ChEMBL. | 2840501 |
MIC (functional) | = 6.2 ug ml-1 | In vitro Minimum inhibitory concentration against Staphylococcus aureus CMX 686B | ChEMBL. | 2840501 |
MIC (functional) | = 6.2 ug ml-1 | In vitro Minimum inhibitory concentration against Staphylococcus aureus A5177 | ChEMBL. | 2840501 |
MIC (functional) | = 12.5 ug ml-1 | In vitro Minimum inhibitory concentration against Staphylococcus aureus 45 | ChEMBL. | 2840501 |
MIC (functional) | = 12.5 ug ml-1 | In vitro Minimum inhibitory concentration against S. epidermidis 3519 | ChEMBL. | 2840501 |
MIC (functional) | = 12.5 ug ml-1 | In vitro Minimum inhibitory concentration against S. agalactiae CMX 508 | ChEMBL. | 2840501 |
MIC (functional) | = 12.5 ug ml-1 | In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa 5007 | ChEMBL. | 2840501 |
MIC (functional) | = 12.5 ug ml-1 | In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa K799/WT | ChEMBL. | 2840501 |
MIC (functional) | = 25 ug ml-1 | In vitro Minimum inhibitory concentration against S. faecium ATCC 8043 | ChEMBL. | 2840501 |
MIC (functional) | = 25 ug ml-1 | In vitro Minimum inhibitory concentration against S. pyogenes 930 | ChEMBL. | 2840501 |
MIC (functional) | = 25 ug ml-1 | In vitro Minimum inhibitory concentration against Acinetobacter CMX 669 | ChEMBL. | 2840501 |
MIC (functional) | = 50 ug ml-1 | In vitro Minimum inhibitory concentration against S. bovis A5169 | ChEMBL. | 2840501 |
Solubility (ADMET) | = 0.06 mg ml-1 | Compound was evaluated for the solubility in Ringer's buffer solution | ChEMBL. | 2840501 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Escherichia coli | ChEMBL23 | 2840501 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.