Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Cathepsin F homolog | 0.0023 | 0.0101 | 0.0101 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0637 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0637 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0637 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0101 | 0.0101 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0637 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0637 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0637 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | fibroinase | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | cysteine protease | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0637 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Plasmodium vivax | vivapain-2 | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0101 | 0.0101 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0637 | 1 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0637 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0101 | 0.0101 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0637 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Toxoplasma gondii | cathepsin CPL | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Plasmodium vivax | RNA helicase-1, putative | 0.0637 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0637 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0023 | 0.0101 | 0.0101 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0101 | 0.0101 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0637 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0101 | 0.0101 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0637 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0637 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0637 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cysteine peptidase A (CPA) | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0101 | 0.0101 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0637 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0637 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0023 | 0.0101 | 0.0101 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0101 | 0.0101 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0637 | 1 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0023 | 0.0101 | 0.0101 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0637 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0023 | 0.0101 | 0.0101 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | ctsf protein | 0.0023 | 0.0101 | 0.0101 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Onchocerca volvulus | 0.0023 | 0.0101 | 0.0101 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0023 | 0.0101 | 0.0101 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0637 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0101 | 0.0101 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0637 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0101 | 0.0101 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0023 | 0.0101 | 0.0101 |
Plasmodium vivax | vivapain-2 | 0.0023 | 0.0101 | 0.0101 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | NA 0 uM | Effective concentration of compound against HIV-1 infected CEM/O cells; No activity up to > 250 uM | ChEMBL. | No reference |
EC50 (functional) | NA 0 uM | Effective concentration of compound against HIV-2 infected CEM/O cells; No activity up to > 250 uM | ChEMBL. | No reference |
EC50 (functional) | NA 0 uM | Cytotoxic activity of the compound was evaluated against CEM/O cells; No activity up to > 250 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.