Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0795 | 1 | 1 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0795 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0062 | 0.0555 | 0.5 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0062 | 0.0555 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0795 | 1 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0062 | 0.0555 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0795 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0795 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0795 | 1 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0062 | 0.0555 | 0.5 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0795 | 1 | 1 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0062 | 0.0555 | 0.5 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0062 | 0.0555 | 0.5 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0045 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0062 | 0.0555 | 0.5 |
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 1 ng ml-1 | In vitro antitumor activity against A204 rhabdomyosarcoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 1 ng ml-1 | In vitro antitumor activity against A204 rhabdomyosarcoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 29 ng ml-1 | In vitro antitumor activity against WiDr colon carcinoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 29 ng ml-1 | In vitro antitumor activity against WiDr colon carcinoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 118 ng ml-1 | In vitro antitumor activity against L1210 lymphocytic leukiemia tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 118 ng ml-1 | In vitro antitumor activity against L1210 lymphocytic leukiemia tumor cell line was determined | ChEMBL. | 2500528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.