Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0023 | 0.0074 | 0.0074 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0726 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0074 | 0.0074 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0726 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cysteine peptidase A (CPA) | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0726 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0726 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0726 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0074 | 0.0074 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0726 | 1 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0023 | 0.0074 | 0.0074 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0074 | 0.0074 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0726 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0023 | 0.0074 | 0.0074 |
Echinococcus granulosus | cathepsin l1 | 0.0023 | 0.0074 | 0.0074 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | ctsf protein | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0726 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0074 | 0.0074 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0726 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0074 | 0.0074 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0023 | 0.0074 | 0.0074 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0726 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0023 | 0.0074 | 0.0074 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0726 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0726 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0074 | 0.0074 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0726 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0726 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0023 | 0.0074 | 0.0074 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Plasmodium vivax | vivapain-2 | 0.0023 | 0.0074 | 0.0074 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0023 | 0.0074 | 0.0074 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0726 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0074 | 0.0074 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0074 | 0.0074 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0726 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0074 | 0.0074 |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0074 | 0.0074 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Toxoplasma gondii | cathepsin CPL | 0.0023 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0074 | 0.0074 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0726 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0023 | 0.0074 | 0.0074 |
Plasmodium vivax | RNA helicase-1, putative | 0.0726 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0074 | 0.0074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Ability to inhibit the binding of P-selectin glycoprotein ligand 1 (PSGL-1) fusion protein to immobilized soluble P-selectin in a P-selectin assay. | ChEMBL. | 11931610 |
Inhibition (binding) | = 30 % | Ability to inhibit the binding of P-selectin glycoprotein ligand 1 (PSGL-1) fusion protein to immobilized soluble P-selectin in a P-selectin assay. | ChEMBL. | 11931610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.