Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0103 | 0.2038 | 1 |
Leishmania major | ribonuclease H1, putative | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0108 | 0.2203 | 0.2499 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0082 | 0.1395 | 0.633 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4384 | 0.4384 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0073 | 0.1114 | 0.0625 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Schistosoma mansoni | single-minded | 0.0108 | 0.2203 | 0.2499 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0103 | 0.2038 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0194 | 0.4809 | 0.6391 |
Toxoplasma gondii | ribonuclease HI protein | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0067 | 0.0929 | 0.0936 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0073 | 0.1114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Mycobacterium ulcerans | putative regulatory protein | 0.008 | 0.1342 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0194 | 0.4809 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.109 | 0.0593 |
Brugia malayi | hypoxia-induced factor 1 | 0.0335 | 0.9139 | 0.9091 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.7226 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Brugia malayi | PAS domain containing protein | 0.0108 | 0.2203 | 0.1767 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | hypothetical protein | 0.0082 | 0.1395 | 0.633 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0054 | 0.0529 | 0.0529 |
Giardia lamblia | Ribonuclease H | 0.0073 | 0.1114 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | Protein-tyrosine phosphatase | 0.019 | 0.4711 | 0.4416 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0079 | 0.1303 | 0.0309 |
Echinococcus multilocularis | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0079 | 0.1303 | 0.0309 |
Trypanosoma brucei | RNA helicase, putative | 0.0273 | 0.7226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0335 | 0.9139 | 0.9139 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0103 | 0.2038 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0079 | 0.1303 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | ribonuclease H1 | 0.0073 | 0.1114 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0067 | 0.0929 | 0.0936 |
Echinococcus granulosus | carboxylesterase 5A | 0.0072 | 0.109 | 0.1311 |
Onchocerca volvulus | 0.008 | 0.1342 | 0.2153 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | single minded 2 | 0.008 | 0.1342 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.01 | 0.1945 | 0.9468 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0929 | 0.0929 |
Echinococcus multilocularis | transfer RNA-Lys | 0.008 | 0.1342 | 0.19 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | carboxylesterase | 0.0072 | 0.109 | 0.109 |
Brugia malayi | bHLH-PAS transcription factor | 0.008 | 0.1342 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0173 | 0.4167 | 0.4167 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0194 | 0.4809 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0072 | 0.109 | 0.0593 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.109 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | RNase H family protein | 0.0073 | 0.1114 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.398 | 0.398 |
Echinococcus multilocularis | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0067 | 0.0929 | 0.0423 |
Echinococcus granulosus | ribonuclease H1 | 0.0073 | 0.1114 | 0.1368 |
Onchocerca volvulus | 0.0177 | 0.4307 | 1 | |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0103 | 0.2038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0103 | 0.2038 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0072 | 0.109 | 0.1311 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0079 | 0.1303 | 0.0309 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0072 | 0.109 | 0.0838 |
Schistosoma mansoni | phosphoglucomutase | 0.0073 | 0.1114 | 0.0874 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0054 | 0.0529 | 0.0529 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0091 | 0.1663 | 0.1198 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0103 | 0.2038 | 1 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0073 | 0.1114 | 0.155 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0103 | 0.2038 | 0.1594 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0054 | 0.0529 | 0.0529 |
Echinococcus granulosus | acetylcholinesterase | 0.0072 | 0.109 | 0.1311 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0529 | 0.0529 |
Trypanosoma brucei | unspecified product | 0.0079 | 0.1303 | 0.0309 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Affinity constant (binding) | = 0.015 uM | In vitro affinity constant against beta-2 adrenergic receptor from guinea pig trachea | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.015 uM | In vitro affinity constant against beta-2 adrenergic receptor from guinea pig trachea | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.15 uM | In vitro affinity constant against beta-1 adrenergic receptor from guinea pig artia | ChEMBL. | 6138434 |
Affinity constant (binding) | = 0.15 uM | In vitro affinity constant against beta-1 adrenergic receptor from guinea pig artia | ChEMBL. | 6138434 |
ED50 (binding) | = 150 ug kg-1 | Beta-2 adrenergic receptor blockade measured as inhibition of depressor response caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
ED50 (binding) | = 150 ug kg-1 | Beta-2 adrenergic receptor blockade measured as inhibition of depressor response caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
ED50 (functional) | = 384 ug kg-1 | Beta1-adrenoceptor blockade measured as inhibition of tachycardia caused by isoprenaline in anesthetized rats when administered intravenously | ChEMBL. | 6138434 |
Ratio (binding) | = 0.1 | Ratio of Beta-2(trachea) to Beta-1(Atria) adrenoceptor affinity constants from guinea pig | ChEMBL. | 6138434 |
Ratio (functional) | = 0.39 | Ratio of rat Beta-2 to Beta-1 adrenoceptor antagonism | ChEMBL. | 6138434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.