Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0188 | 0.5056 | 0.6121 |
Echinococcus multilocularis | histone deacetylase 6 | 0.023 | 0.7286 | 0.8821 |
Schistosoma mansoni | histone deacetylase hda2 | 0.023 | 0.7286 | 0.7286 |
Loa Loa (eye worm) | histone deacetylase | 0.0223 | 0.6945 | 0.6945 |
Schistosoma mansoni | histone deacetylase | 0.0248 | 0.826 | 0.826 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0281 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0094 | 0.0037 | 0.0045 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0107 | 0.0732 | 0.0886 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0248 | 0.826 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0107 | 0.0732 | 0.0732 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0281 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0248 | 0.826 | 0.5 |
Echinococcus granulosus | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8401 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0188 | 0.5056 | 0.6104 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Brugia malayi | Histone deacetylase 1 | 0.0248 | 0.826 | 0.826 |
Echinococcus granulosus | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0248 | 0.826 | 0.826 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0223 | 0.6945 | 0.6945 |
Trypanosoma brucei | histone deacetylase 3 | 0.0223 | 0.6945 | 0.8254 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Brugia malayi | Histone deacetylase family protein | 0.0223 | 0.6945 | 0.6945 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0248 | 0.826 | 0.648 |
Leishmania major | histone deacetylase, putative | 0.0248 | 0.826 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0223 | 0.6945 | 0.8254 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0223 | 0.6945 | 0.6945 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0107 | 0.0732 | 0.5 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0248 | 0.826 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0223 | 0.6945 | 0.6945 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0094 | 0.0037 | 0.0045 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0107 | 0.0732 | 0.0732 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0223 | 0.6945 | 0.8409 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0094 | 0.0037 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.826 | 0.826 |
Trypanosoma brucei | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0223 | 0.6945 | 0.8254 |
Schistosoma mansoni | histone deacetylase | 0.0248 | 0.826 | 0.826 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0107 | 0.0732 | 0.0732 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Plasmodium vivax | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.127 | 0.127 |
Echinococcus granulosus | histone deacetylase 8 | 0.0107 | 0.0732 | 0.0844 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | histone deacetylase | 0.0223 | 0.6945 | 0.8409 |
Leishmania major | histone deacetylase, putative | 0.0248 | 0.826 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0248 | 0.826 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8409 |
Plasmodium falciparum | histone deacetylase 1 | 0.0248 | 0.826 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0223 | 0.6945 | 0.8254 |
Schistosoma mansoni | serine/threonine kinase | 0.0281 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.023 | 0.7286 | 0.8815 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.161 | 0.161 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0223 | 0.6945 | 0.8254 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8409 |
Echinococcus granulosus | histone deacetylase 6 | 0.0223 | 0.6945 | 0.8401 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0732 | 0.0732 |
Giardia lamblia | Histone deacetylase | 0.0248 | 0.826 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0248 | 0.826 | 0.826 |
Echinococcus granulosus | histone deacetylase 3 | 0.0248 | 0.826 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0248 | 0.826 | 0.826 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0107 | 0.0732 | 0.0732 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0248 | 0.826 | 0.826 |
Echinococcus granulosus | histone deacetylase | 0.0223 | 0.6945 | 0.8401 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0248 | 0.826 | 0.648 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0248 | 0.826 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0223 | 0.6945 | 0.8401 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0223 | 0.6945 | 0.6945 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 0.94 mmol/Kg | Toxicity in ip dosed BDF1 mouse assessed as animal killed administered as single dose | ChEMBL. | 722732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.