Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Blockade of voltage-activated rat Kv1.1 potassium channel expressed in Xenopus laevis oocytes assessed as effect on evoked current upto 10 uM by two-electrode voltage clamp method | ChEMBL. | 12444689 | |
Activity (binding) | Blockade of voltage-activated rat Kv1.4 potassium channel expressed in Xenopus laevis oocytes assessed as effect on evoked current upto 10 uM by two-electrode voltage clamp method | ChEMBL. | 12444689 | |
Activity (binding) | Blockade of voltage-activated rat brain Nav1.2 sodium channel type 2 channel expressed in Xenopus laevis oocytes assessed as effect on evoked current by two-electrode voltage clamp method | ChEMBL. | 12444689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.