Detailed view for ML1192

Basic information

TDR Targets ID: 979799
Mycobacterium leprae, HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE
Source Database / ID:  Leproma 

pI: 6.979 | Length (AA): 130 | MW (Da): 14105 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Pantothenate and CoA biosynthesis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 129 4hc6 (A) 2 129 86.00 0 1 2.06912 -1.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130884)

Species Accession Gene Product
Candida albicans CaO19.12275   similar to holo-(acyl carrier protein) synthase
Candida albicans CaO19.4812   similar to holo-(acyl carrier protein) synthase
Chlamydia trachomatis CT_100   holo [acyl-carrier protein] synthase
Dictyostelium discoideum DDB_G0275923   hypothetical protein
Escherichia coli b2563   holo-[acyl-carrier-protein] synthase 1
Mycobacterium leprae ML1192   HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE
Mycobacterium tuberculosis Rv2523c   holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie
Mycobacterium ulcerans MUL_3817   4'-phosphopantetheinyl transferase
Plasmodium berghei PBANKA_0521600   holo-[acyl-carrier-protein] synthase, putative
Plasmodium falciparum PF3D7_0420200   holo-[acyl-carrier-protein] synthase, putative
Plasmodium knowlesi PKNH_0513000   holo-[acyl-carrier-protein] synthase, putative
Plasmodium vivax PVX_090105   holo-[acyl-carrier-protein] synthase, putative
Plasmodium yoelii PY06285   hypothetical protein
Saccharomyces cerevisiae YPL148C   Ppt2p
Treponema pallidum TP0828   4'-phosphopantetheinyl transferase
Wolbachia endosymbiont of Brugia malayi Wbm0078   4'-phosphopantetheinyl transferase

Essentiality

ML1192 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2566 Mycobacterium tuberculosis non-essential nmpdr
b2563 Escherichia coli essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bacillus subtilis (strain 168) Holo-[acyl-carrieir-protein] synthase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0341 0.4359 1
0.0963 0.4738 1
0.0115 0.597 0.3392
0.0686 0.7947 1
0.0795 0.8005 1
0.0098 0.6782 0.5
0.0297 0.5819 1
0.02 0.7924 1
0.01 0.5386 1
0.0297 0.5819 1
0.0486 0.7876 1
0.0092 0.7166 1
0.0092 0.2649 1
0.0781 0.4883 1
0.0096 0.7155 0.5
0.0092 0.7108 0.5
0.0092 0.2649 1
0.0093 0.7179 1
0.0115 0.5037 0.5
0.0783 0.754 1
0.0482 0.8012 1
0.0708 0.5436 1
0.02 0.7924 1
0.0596 0.7581 1
0.0596 0.7581 1
0.0708 0.5436 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier ML1192 (Mycobacterium leprae), HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE
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