Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1025 | 0.9945 | 0.993 |
Onchocerca volvulus | 0.0414 | 0.2523 | 0.0379 | |
Schistosoma mansoni | cell polarity protein | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.1021 | 0.9892 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Loa Loa (eye worm) | hypothetical protein | 0.1021 | 0.9892 | 0.9861 |
Onchocerca volvulus | Arrow homolog | 0.1025 | 0.9945 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Brugia malayi | Muscle positioning protein 4 | 0.0414 | 0.2523 | 0.0379 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1026 | 0.9947 | 0.9931 |
Echinococcus multilocularis | Tolloid protein 1 | 0.1026 | 0.9947 | 1 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Giardia lamblia | High cysteine protein | 0.039 | 0.223 | 0.5 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.039 | 0.223 | 0.2242 |
Loa Loa (eye worm) | hypothetical protein | 0.1026 | 0.9947 | 0.9931 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.1025 | 0.9945 | 0.993 |
Echinococcus multilocularis | laminin | 0.1021 | 0.9892 | 0.9929 |
Echinococcus granulosus | laminin | 0.1021 | 0.9892 | 0.9929 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.1025 | 0.9945 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.039 | 0.223 | 0.2242 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.1021 | 0.9892 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.1021 | 0.9892 | 0.9861 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1026 | 0.9947 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1021 | 0.9892 | 0.9861 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2523 | 0.0377 |
Brugia malayi | Fibulin-1 precursor | 0.1021 | 0.9892 | 0.9931 |
Echinococcus granulosus | Tolloid protein 1 | 0.1026 | 0.9947 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.021 | 0.0053 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.2285 | 0.007 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0394 | 0.2285 | 0.0071 |
Schistosoma mansoni | slit | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | egf-like domain protein | 0.1021 | 0.9892 | 0.9945 |
Onchocerca volvulus | Putative cubilin | 0.0394 | 0.2285 | 0.0071 |
Echinococcus multilocularis | fibrillin 1 | 0.1021 | 0.9892 | 0.9929 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.1021 | 0.9892 | 0.9931 |
Schistosoma mansoni | septate junction protein | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | notch | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.223 | 0.2242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0 uM | In vitro Inhibitory activity against the growth of L1210 murine lymphocytic leukemia at =10 uM concentration; Inactive | ChEMBL. | 3165132 |
ID50 (functional) | = 0 uM | In vitro Inhibitory activity against the growth of WIL-2 human B lymphoblastic leukemia at =10 uM concentration; Inactive | ChEMBL. | 3165132 |
ID50 (functional) | = 0 uM | In vitro inhibitory activity against the growth of CCRF-CEM human T lymphoblastic leukemia at =10 uM concentration; Inactive | ChEMBL. | 3165132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.