Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0726 | 0.0695 |
Onchocerca volvulus | 0.023 | 0.6329 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0726 | 0.0695 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0347 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0347 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0347 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0219 | 0.0187 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0133 | 0.3283 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.5455 | 0.5439 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4279 | 0.426 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0219 | 0.0187 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0287 | 0.8109 | 0.8102 |
Echinococcus granulosus | geminin | 0.0164 | 0.4279 | 0.4279 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0133 | 0.3283 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0133 | 0.3283 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0133 | 0.3283 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0033 | 0.0033 |
Brugia malayi | Dihydrofolate reductase | 0.0347 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0726 | 0.0695 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.5455 | 0.5439 |
Echinococcus granulosus | dihydrofolate reductase | 0.0347 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0133 | 0.3283 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0347 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0133 | 0.3283 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0726 | 0.0695 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4279 | 0.426 |
Brugia malayi | follicle stimulating hormone receptor | 0.0287 | 0.8109 | 0.8102 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0347 | 1 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.6329 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0347 | 1 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0219 | 0.0187 |
Echinococcus multilocularis | geminin | 0.0164 | 0.4279 | 0.426 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0347 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Live Cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 42.1632 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 51.6144 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.