Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0605 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.4865 | 0.4865 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0325 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0067 | 0.0067 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0067 | 0.0067 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0601 | 0.9923 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0326 | 0.5159 | 0.5199 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0325 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0331 | 0.0331 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0601 | 0.9923 | 0.9923 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0601 | 0.9923 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0605 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0605 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0331 | 0.0331 |
Echinococcus multilocularis | tumor protein p63 | 0.0326 | 0.5159 | 0.5199 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0331 | 0.0331 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0605 | 1 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0601 | 0.9923 | 0.9923 |
Onchocerca volvulus | 0.0048 | 0.0325 | 0.0327 | |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0601 | 0.9923 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0067 | 0.0067 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0601 | 0.9923 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.