Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0841 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0063 | 0 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0063 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0841 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.2182 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2182 | 0.2182 |
Brugia malayi | hypothetical protein | 0.0232 | 0.2182 | 0.2182 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0947 | 0.0947 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0947 | 0.17 |
Trichomonas vaginalis | set domain proteins, putative | 0.0496 | 0.557 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0436 | 0.4796 | 0.4796 |
Brugia malayi | hypothetical protein | 0.0136 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0947 | 0.0947 |
Onchocerca volvulus | 0.0314 | 0.3232 | 0.5803 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.2182 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.043 | 0.4718 | 0.4718 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0947 | 0.17 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0436 | 0.4796 | 0.4796 |
Plasmodium vivax | SET domain protein, putative | 0.0063 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0841 | 1 | 1 |
Onchocerca volvulus | 0.0496 | 0.557 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 88 % | Compound was tested for percent of fraction inhibition by anti-P-450 NF. | ChEMBL. | 3746811 |
Inhibition (ADMET) | = 88 % | Compound was tested for percent of fraction inhibition by anti-P-450 NF. | ChEMBL. | 3746811 |
Log 1/EC50 (functional) | = 8.12 | Effective concentration required to produce mechanical response determined in muscle strips of guinea pig | ChEMBL. | 2846838 |
Log 1/IC50 (functional) | = 8.37000000000001 | Compound was tested for its antagonist activity against calcium channel | ChEMBL. | 2846838 |
Rate of oxidation (ADMET) | = 0.76 | Rate of Oxidation of the compound in human liver microsomes is measured as mean (nmol product) formed / min per nmol cytochrome P-450 | ChEMBL. | 3746811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.