Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3645 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0021 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.00000014065 | 0.00000014065 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0021 | 0.0021 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3645 | 0.3645 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.00000014065 | 0.00000038591 |
Brugia malayi | Death domain containing protein | 0.0017 | 0.00000014065 | 0.00000038591 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3645 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0021 | 0.0057 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3645 | 0.3645 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.0021 | 0.0021 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.00000014065 | 0.00000038591 |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.00000014065 | 0.00000038591 |
Onchocerca volvulus | Netrin receptor homolog | 0.0017 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3645 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3645 | 0.5 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.00000014065 | 0.00000014065 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5355 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.4941 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.6854 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 34.3762 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of androgen receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.941 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.