Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.000000068055 | 0.00000010159 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.000000068055 | 0.000000068055 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.001 | 0.001 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5494 | 0.8202 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.000000068055 | 0.00000010159 |
Brugia malayi | bZIP transcription factor family protein | 0.0101 | 0.5682 | 0.8483 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.4838 | 0.4838 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.000000068055 | 0.000000068055 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.001 | 0.001 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.6699 | 1 |
Onchocerca volvulus | 0.008 | 0.421 | 1 | |
Echinococcus multilocularis | jun protein | 0.0101 | 0.5682 | 0.5682 |
Brugia malayi | Death domain containing protein | 0.0017 | 0.000000068055 | 0.00000010159 |
Brugia malayi | hypothetical protein | 0.008 | 0.421 | 0.6285 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.4398 | 0.4398 |
Schistosoma mansoni | jun-related protein | 0.0082 | 0.4398 | 0.4398 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0101 | 0.5682 | 0.5682 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.4838 | 0.4838 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.000000068055 | 0.000000068055 |
Echinococcus granulosus | jun protein | 0.0101 | 0.5682 | 0.5682 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.001 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0101 | 0.5682 | 0.5682 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.6699 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.6699 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.