Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0131 | 0.3118 | 0.3067 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0842 | 0.0773 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0123 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1529 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1628 | 0.5033 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.1927 | 0.5995 |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.2171 | 0.6817 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0273 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0273 |
Brugia malayi | Endochitinase | 0.0012 | 0.0197 | 0.0273 |
Brugia malayi | Endochitinase | 0.0093 | 0.2171 | 0.6846 |
Entamoeba histolytica | chitinase, putative | 0.0083 | 0.1927 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0093 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.1927 | 0.5995 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Plasmodium vivax | hypothetical protein, conserved | 0.0131 | 0.3118 | 1 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0083 | 0.1927 | 0.6028 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0012 | 0.0197 | 0.0123 |
Onchocerca volvulus | Putative endochitinase | 0.0012 | 0.0197 | 0.0182 |
Brugia malayi | endochitinase | 0.0093 | 0.2171 | 0.6846 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3118 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Schistosoma mansoni | chitinase | 0.0012 | 0.0197 | 0.0197 |
Onchocerca volvulus | 0.0131 | 0.3118 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.164 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0412 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0093 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.001 | 0.0143 | 0.0084 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1529 | 0.4707 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0131 | 0.3118 | 0.3067 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Onchocerca volvulus | 0.0029 | 0.0608 | 0.1562 | |
Loa Loa (eye worm) | chitinase I | 0.0083 | 0.1927 | 0.6028 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0412 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.3118 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Mycobacterium tuberculosis | Possible chitinase | 0.007 | 0.1628 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0264 |
Leishmania major | chitinase | 0.0083 | 0.1927 | 1 |
Onchocerca volvulus | Putative chitinase | 0.0012 | 0.0197 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0197 | 0.0264 |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.2171 | 0.6817 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0131 | 0.3118 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0648 | 0.0578 |
Mycobacterium ulcerans | chitinase/cellulase | 0.007 | 0.1628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Trichomonas vaginalis | chitinase, putative | 0.0012 | 0.0197 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0131 | 0.3118 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1529 | 0.4702 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0648 | 0.0648 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0197 | 0.0273 |
Loa Loa (eye worm) | microfilarial chitinase | 0.008 | 0.1872 | 0.5848 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1632 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0842 | 0.0773 |
Mycobacterium ulcerans | chitinase/cellulase | 0.007 | 0.1628 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.001 | 0.0143 | 0.0093 |
Brugia malayi | endochitinase | 0.0083 | 0.1927 | 0.6032 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0012 | 0.0197 | 0.0264 |
Plasmodium falciparum | conserved protein, unknown function | 0.0131 | 0.3118 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1529 | 0.1465 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0012 | 0.0197 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0143 | 0.0084 |
Onchocerca volvulus | 0.0131 | 0.3118 | 1 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1529 | 0.7699 |
Onchocerca volvulus | Putative endochitinase | 0.0093 | 0.2171 | 0.6817 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.3118 | 0.3118 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to wild type Staphylococcus aureus alpha-hemolysin by fluorescence quenching method | ChEMBL. | 23376250 | |
Activity (functional) | = -19.81 % | Antitumor activity against human BGC823 cells | ChEMBL. | 20708932 |
Activity (functional) | = -7.68 % | Antitumor activity against human Bel7402 cells | ChEMBL. | 20708932 |
Activity (functional) | = -4.85 % | Antitumor activity against human HL60 cells | ChEMBL. | 20708932 |
Activity (functional) | = 45.3 % | Antitumor activity against human KB cells | ChEMBL. | 20708932 |
EC50 (functional) | > 20 uM | Cytoprotectant activity against H2O2-induced injury in HUVEC cells | ChEMBL. | 20708932 |
Inhibition (binding) | Inhibition of purified Staphylococcus aureus alpha-hemolysin-induced hemolysis of rabbit erythrocytes after 20 mins by spectrophotometry | ChEMBL. | 23376250 | |
Inhibition (binding) | Inhibition of deoxycholate-induced wild type Staphylococcus aureus alpha-hemolysin oligomerization at 16 ug/ml by SDS-PAGE analysis | ChEMBL. | 23376250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.